tetano
Editor, Senior Moderator
Am J Clin Pathol
. 2021 Jun 21;aqab052.
doi: 10.1093/ajcp/aqab052. Online ahead of print.
Comparison of Blood Counts and Markers of Inflammation and Coagulation in Patients With and Without COVID-19 Presenting to the Emergency Department in Seattle, WA
Christopher M Chandler[SUP] 1 [/SUP], Molly C Reid[SUP] 2 [/SUP], Sindhu Cherian[SUP] 1 [/SUP], Daniel E Sabath[SUP] 1 [/SUP], Kerstin L Edlefsen[SUP] 1 [/SUP]
Affiliations
Abstract
Objectives: We compared complete blood count (CBC) with differential and markers of inflammation and coagulation in patients with and without coronavirus disease 2019 (COVID-19) presenting to emergency departments in Seattle, WA.
Methods: We reviewed laboratory values for 1 week following each COVID-19 test for adult patients who received a standard severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reverse transcription polymerase chain reaction (RT-PCR) test before April 13, 2020. Results were compared by COVID-19 status and clinical course.
Results: In total 1,027 patients met inclusion criteria. Patients with COVID-19 (n = 155) had lower leukocytes (P < .0001), lymphocytes (P < .0001), platelets (P < .0001), and higher hemoglobin (P = .0140) than those without, but absolute differences were small. Serum albumin was lower in patients with COVID-19 (P < .0001) and serum albumin, neutrophil to lymphocyte ratio (NLR), and red cell distribution width (RDW) were each associated with disease severity. NLR did not differ between patients with COVID-19 and those without (P = .8012).
Conclusions: Patients with COVID-19 had modestly lower leukocyte, lymphocyte, and platelet counts and higher hemoglobin values than patients without COVID-19. The NLR, serum albumin, and RDW varied with disease severity, regardless of COVID-19 status.
Keywords: COVID-19; Emergency department; Laboratory testing; Neutrophil to lymphocyte ratio; SARS-CoV-2.
. 2021 Jun 21;aqab052.
doi: 10.1093/ajcp/aqab052. Online ahead of print.
Comparison of Blood Counts and Markers of Inflammation and Coagulation in Patients With and Without COVID-19 Presenting to the Emergency Department in Seattle, WA
Christopher M Chandler[SUP] 1 [/SUP], Molly C Reid[SUP] 2 [/SUP], Sindhu Cherian[SUP] 1 [/SUP], Daniel E Sabath[SUP] 1 [/SUP], Kerstin L Edlefsen[SUP] 1 [/SUP]
Affiliations
- PMID: 34151348
- DOI: 10.1093/ajcp/aqab052
Abstract
Objectives: We compared complete blood count (CBC) with differential and markers of inflammation and coagulation in patients with and without coronavirus disease 2019 (COVID-19) presenting to emergency departments in Seattle, WA.
Methods: We reviewed laboratory values for 1 week following each COVID-19 test for adult patients who received a standard severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reverse transcription polymerase chain reaction (RT-PCR) test before April 13, 2020. Results were compared by COVID-19 status and clinical course.
Results: In total 1,027 patients met inclusion criteria. Patients with COVID-19 (n = 155) had lower leukocytes (P < .0001), lymphocytes (P < .0001), platelets (P < .0001), and higher hemoglobin (P = .0140) than those without, but absolute differences were small. Serum albumin was lower in patients with COVID-19 (P < .0001) and serum albumin, neutrophil to lymphocyte ratio (NLR), and red cell distribution width (RDW) were each associated with disease severity. NLR did not differ between patients with COVID-19 and those without (P = .8012).
Conclusions: Patients with COVID-19 had modestly lower leukocyte, lymphocyte, and platelet counts and higher hemoglobin values than patients without COVID-19. The NLR, serum albumin, and RDW varied with disease severity, regardless of COVID-19 status.
Keywords: COVID-19; Emergency department; Laboratory testing; Neutrophil to lymphocyte ratio; SARS-CoV-2.