tetano
Editor, Senior Moderator
Am J Cardiovasc Dis
. 2020 Oct 15;10(4):386-391.
eCollection 2020.
Systemic microvascular dysfunction in COVID-19
Leticia R Sabioni[SUP] 1 [/SUP], Eduardo Tibirica[SUP] 1 [/SUP], Cristiane C Lamas[SUP] 1 [/SUP], Guilherme D Amorim[SUP] 1 [/SUP], Andrea De Lorenzo[SUP] 1 [/SUP]
Affiliations
Abstract
COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), while having lung injury as its most prominent feature, has been increasingly shown to affect endothelial cell function and the microvasculature. In this report, a woman with COVID-19, cardiac valve disease and spherocytosis was assessed with laser Doppler perfusion monitoring. Systemic microvascular reactivity was impaired during a worsening phase of COVID-19, but improved after clinical recovery; microcirculatory dysfunction paralleled systemic inflammation and pulmonary involvement. The assessment of systemic microcirculatory function may therefore provide insights on COVID-19 pathophysiology.
Keywords: COVID-19; cardiac valve disease; endothelial dysfunction; laser Doppler perfusion imaging; microvascular reactivity.
. 2020 Oct 15;10(4):386-391.
eCollection 2020.
Systemic microvascular dysfunction in COVID-19
Leticia R Sabioni[SUP] 1 [/SUP], Eduardo Tibirica[SUP] 1 [/SUP], Cristiane C Lamas[SUP] 1 [/SUP], Guilherme D Amorim[SUP] 1 [/SUP], Andrea De Lorenzo[SUP] 1 [/SUP]
Affiliations
- PMID: 33224588
- PMCID: PMC7675177
Abstract
COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), while having lung injury as its most prominent feature, has been increasingly shown to affect endothelial cell function and the microvasculature. In this report, a woman with COVID-19, cardiac valve disease and spherocytosis was assessed with laser Doppler perfusion monitoring. Systemic microvascular reactivity was impaired during a worsening phase of COVID-19, but improved after clinical recovery; microcirculatory dysfunction paralleled systemic inflammation and pulmonary involvement. The assessment of systemic microcirculatory function may therefore provide insights on COVID-19 pathophysiology.
Keywords: COVID-19; cardiac valve disease; endothelial dysfunction; laser Doppler perfusion imaging; microvascular reactivity.