Alterations in T and B cell function persist in convalescent COVID-19 patients

[Mary Wilson]

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Accepted: March 19, 2021
Published:March 31, 2021
DOI:https://doi.org/10.1016/j.medj.2021.03.013

Halima A. Shuwa, Tovah N. Shaw, Sean B. Knight, Kelly Wemyss, Flora A. McClure, Laurence Pearmain, Ian Prise, Christopher Jagger, David.J. Morgan, Saba Khan, Oliver Brand, Elizabeth R. Mann, Andrew Ustianowski, Nawar Diar Bakerly, Paul Dark, Christopher E. Brightling, Seema Brij, CIRCO, Timothy Felton, Angela Simpson, John R. Grainger, Tracy Hussell, Joanne E. Konkel, Madhvi Menon

Highlights

• 1. Lymphocytes were examined during COVID-19 and at up to 6 months of convalescence
• 2. B cell changes seen during acute COVID-19 were largely restored in convalescence
• 3. T cells from convalescent COVID-19 patients displayed persistent changes
• 4. Lymphocyte signatures defined 3 convalescent patient groups; one with poorer outcome

Full Text in PDF Format:
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