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Alcelaphine herpesvirus 1 (AlHV-1) causes malignant catarrhal fever (MCF) ?

Shiloh

Editor, Senior Moderator
Source: http://www.the-scientist.com/?artic...0/title/Virus-Latency-Causes-Cattle-Disease-/


Virus Latency Causes Cattle Disease?
Researchers identify a herpesvirus gene persisting in cells of calves suffering from malignant catarrhal disease.
By Sabrina Richards | April 29, 2013


Cattle can contract malignant catarrhal fever (MCF), an often-fatal disease in which activated immune cells accumulate and cause tissue damage, from wildebeests asymptomatically infected with the alcelaphine herpesvirus 1 (AlHV-1). Now, researchers demonstrated that MCF requires the persistence of the herpesvirus genome in infected cows. Removing the gene responsible for AlHV-1 latency helps protect the animals against the disease, pointing to a new vaccine strategy to protect livestock...
 
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