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Imaging Findings in a Fatal Case of Pandemic Swine-Origin Influenza A (H1N1)
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Daniel J. Mollura,Deborah S. Asnis, Rick Conetta, David S. Feigin, Mike Bray, Jeffery K. Taubenberger, David A. Bluemke
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OBJECTIVE. Although most cases of swine-origin influenza A (H1N1) virus (S-OIV) <o></o> have been self-limited, fatal cases raise questions about virulence and radiology?s role in early detection. We describe the radiographic and CT findings in a fatal S-OIV infection. <o></o>
CONCLUSION. Radiography showed peripheral lung opacities. CT revealed peripheral <o></o> ground-glass opacities suggesting peribronchial injury. These imaging findings raised suspicion of S-OIV despite negative H1N1 influenza rapid antigen test results from two nasopharyngeal swabs; subsequently, those results were proven to be false-negatives by reverse transcriptase polymerase chain reaction. This case suggests a role for CT in the early recognition of severe S-OIV.
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Link to full article (ahead of print) in American Journal of Roentgenology (AJR 2009; 193:1?4):
http://www.ajronline.org/aheadofprint/12_09_3365.pdf
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> </o> Daniel J. Mollura,Deborah S. Asnis, Rick Conetta, David S. Feigin, Mike Bray, Jeffery K. Taubenberger, David A. Bluemke
<o
> </o>OBJECTIVE. Although most cases of swine-origin influenza A (H1N1) virus (S-OIV) <o
></o> have been self-limited, fatal cases raise questions about virulence and radiology?s role in early detection. We describe the radiographic and CT findings in a fatal S-OIV infection. <o></o>CONCLUSION. Radiography showed peripheral lung opacities. CT revealed peripheral <o
></o> ground-glass opacities suggesting peribronchial injury. These imaging findings raised suspicion of S-OIV despite negative H1N1 influenza rapid antigen test results from two nasopharyngeal swabs; subsequently, those results were proven to be false-negatives by reverse transcriptase polymerase chain reaction. This case suggests a role for CT in the early recognition of severe S-OIV.<o
> </o>Link to full article (ahead of print) in American Journal of Roentgenology (AJR 2009; 193:1?4):
http://www.ajronline.org/aheadofprint/12_09_3365.pdf