tetano
Editor, Senior Moderator
AJP Rep
. 2020 Jul;10(3):e270-e274.
doi: 10.1055/s-0040-1715177. Epub 2020 Sep 16.
In Utero Vertical Transmission of Coronavirus Disease 2019 in a Severely Ill 29-week Preterm Infant
Arpit Gupta[SUP] 1 [/SUP], Yogangi Malhotra[SUP] 2 [/SUP], Uday Patil[SUP] 3 [/SUP], Ana R Muradas[SUP] 1 [/SUP], William T Lee[SUP] 4 [/SUP], Florian Krammer[SUP] 5 [/SUP], Fatima Amanat[SUP] 5 [/SUP], Camille A Clare[SUP] 6 [/SUP], Suja Vinod[SUP] 1 [/SUP], Emad Ghaly[SUP] 1 [/SUP]
Affiliations
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) or coronavirus disease 2019 (COVID-19) is currently in worldwide pandemic state with very limited data about the mode of transmission to the growing fetus. There are a few published cases of COVID-19 infection in the infants born to COVID-19 positive mothers where most of the reported cases were either mildly symptomatic with positive COVID-19 polymerase chain reaction (PCR) or had negative COVID-19 PCR raising the question of vertical transmission. We present a case of likely intrauterine transmission of COVID-19 infection in a critically ill premature infant born to a COVID-19 infected mother and describing her clinical course thus far. The clinical presentation in the infant is consistent with COVID-19 infection described so far in literature along with positive PCR, and positive COVID-19 serology: immunoglobulin G, immunoglobulin M, and immunoglobulin A.
Keywords: Severe acute respiratory syndrome coronavirus 2; coronavirus disease 2019; intrauterine; newborn; preterm; vertical transmission.
. 2020 Jul;10(3):e270-e274.
doi: 10.1055/s-0040-1715177. Epub 2020 Sep 16.
In Utero Vertical Transmission of Coronavirus Disease 2019 in a Severely Ill 29-week Preterm Infant
Arpit Gupta[SUP] 1 [/SUP], Yogangi Malhotra[SUP] 2 [/SUP], Uday Patil[SUP] 3 [/SUP], Ana R Muradas[SUP] 1 [/SUP], William T Lee[SUP] 4 [/SUP], Florian Krammer[SUP] 5 [/SUP], Fatima Amanat[SUP] 5 [/SUP], Camille A Clare[SUP] 6 [/SUP], Suja Vinod[SUP] 1 [/SUP], Emad Ghaly[SUP] 1 [/SUP]
Affiliations
- PMID: 33094016
- PMCID: PMC7571549
- DOI: 10.1055/s-0040-1715177
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) or coronavirus disease 2019 (COVID-19) is currently in worldwide pandemic state with very limited data about the mode of transmission to the growing fetus. There are a few published cases of COVID-19 infection in the infants born to COVID-19 positive mothers where most of the reported cases were either mildly symptomatic with positive COVID-19 polymerase chain reaction (PCR) or had negative COVID-19 PCR raising the question of vertical transmission. We present a case of likely intrauterine transmission of COVID-19 infection in a critically ill premature infant born to a COVID-19 infected mother and describing her clinical course thus far. The clinical presentation in the infant is consistent with COVID-19 infection described so far in literature along with positive PCR, and positive COVID-19 serology: immunoglobulin G, immunoglobulin M, and immunoglobulin A.
Keywords: Severe acute respiratory syndrome coronavirus 2; coronavirus disease 2019; intrauterine; newborn; preterm; vertical transmission.