tetano
Editor, Senior Moderator
AJP Rep
. 2023 Nov 28;13(4):e78-e81.
doi: 10.1055/s-0043-1777099. eCollection 2023 Jul. A Case of Significant Transaminitis with Liver Biopsy in a Pregnant Patient with COVID-19
Dana Senderoff Berger[SUP] 1 [/SUP], Anna Galyean[SUP] 2 [/SUP], Kelvin Nguyen[SUP] 3 [/SUP], Najeeb Alshak[SUP] 4 [/SUP], Elizabeth Blumenthal[SUP] 2 [/SUP]
Affiliations
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, has led to a global health crisis. The virus can cause varying severity of liver injury, but the mechanism has not yet been elucidated, especially in pregnancy. We present a morbidly obese 30-year-old woman with COVID-19 at 28 weeks' gestation complicated by significant transaminitis with peak liver enzymes levels of 501/1,313 (aspartate aminotransferase/alanine aminotransferase). Liver biopsy showed reactive changes consistent with medication effect and mild steatosis. Significant transaminitis has been found in both pregnant and nonpregnant patients with COVID-19. Our case demonstrates the multifactorial nature of liver injury in COVID-19 patients including mild underlying liver steatosis combined with possible viral potentiation of medication effect.
Keywords: COVID-19; hepatic manifestations; hepatocellular damage; liver; pregnancy; transaminitis; viral injury.
. 2023 Nov 28;13(4):e78-e81.
doi: 10.1055/s-0043-1777099. eCollection 2023 Jul. A Case of Significant Transaminitis with Liver Biopsy in a Pregnant Patient with COVID-19
Dana Senderoff Berger[SUP] 1 [/SUP], Anna Galyean[SUP] 2 [/SUP], Kelvin Nguyen[SUP] 3 [/SUP], Najeeb Alshak[SUP] 4 [/SUP], Elizabeth Blumenthal[SUP] 2 [/SUP]
Affiliations
- PMID: 38033600
- PMCID: PMC10684339
- DOI: 10.1055/s-0043-1777099
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, has led to a global health crisis. The virus can cause varying severity of liver injury, but the mechanism has not yet been elucidated, especially in pregnancy. We present a morbidly obese 30-year-old woman with COVID-19 at 28 weeks' gestation complicated by significant transaminitis with peak liver enzymes levels of 501/1,313 (aspartate aminotransferase/alanine aminotransferase). Liver biopsy showed reactive changes consistent with medication effect and mild steatosis. Significant transaminitis has been found in both pregnant and nonpregnant patients with COVID-19. Our case demonstrates the multifactorial nature of liver injury in COVID-19 patients including mild underlying liver steatosis combined with possible viral potentiation of medication effect.
Keywords: COVID-19; hepatic manifestations; hepatocellular damage; liver; pregnancy; transaminitis; viral injury.