tetano
Editor, Senior Moderator
AJNR Am J Neuroradiol
. 2024 Apr 4.
doi: 10.3174/ajnr.A8167. Online ahead of print. Reduced Cortical Thickness Correlates of Cognitive Dysfunction in Post-COVID-19 Condition: Insights from a Long-Term Follow-up
Rosalia Dacosta-Aguayo[SUP] 1 2 [/SUP], Josep Puig[SUP] 3 4 [/SUP], Noemi Lamonja-Vicente[SUP] 1 5 [/SUP], Meritxell Carmona-Cervelló[SUP] 1 [/SUP], Brenda Biaani León-Gómez[SUP] 1 [/SUP], Gemma Monté-Rubio[SUP] 3 [/SUP], Victor M López-Linfante[SUP] 1 5 6 7 [/SUP], Valeria Zamora-Putin[SUP] 1 6 [/SUP], Pilar Montero-Alia[SUP] 1 5 [/SUP], Carla Chacon[SUP] 1 8 [/SUP], Jofre Bielsa[SUP] 1 [/SUP], Eduard Moreno-Gabriel[SUP] 1 5 9 [/SUP], Rosa Garcia-Sierra[SUP] 1 5 10 [/SUP], Alba Pachón[SUP] 1 [/SUP], Anna Costa[SUP] 1 [/SUP], Maria Mataró[SUP] 2 [/SUP], Julia G Prado[SUP] 11 12 13 [/SUP], Eva Martinez-Cáceres[SUP] 7 13 14 15 [/SUP], Lourdes Mateu[SUP] 12 13 16 17 [/SUP], Marta Massanella[SUP] 11 12 13 17 [/SUP], Concepción Violán[SUP] 18 8 13 19 20 [/SUP], Pere Torán-Monserrat[SUP] 1 5 13 21 [/SUP]; Aliança ProHEpiC-19 Cognitiu (The APC Collaborative Group)
Affiliations
Background and purpose: There is a paucity of data on long-term neuroimaging findings from individuals who have developed the post-coronavirus 2019 (COVID-19) condition. Only 2 studies have investigated the correlations between cognitive assessment results and structural MR imaging in this population. This study aimed to elucidate the long-term cognitive outcomes of participants with the post-COVID-19 condition and to correlate these cognitive findings with structural MR imaging data in the post-COVID-19 condition.
Materials and methods: A cohort of 53 participants with the post-COVID-19 condition underwent 3T brain MR imaging with T1 and FLAIR sequences obtained a median of 1.8 years after Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infection. A comprehensive neuropsychological battery was used to assess several cognitive domains in the same individuals. Correlations between cognitive domains and whole-brain voxel-based morphometry were performed. Different ROIs from FreeSurfer were used to perform the same correlations with other neuroimaging features.
Results: According to the Frascati criteria, more than one-half of the participants had deficits in the attentional (55%, n = 29) and executive (59%, n = 31) domains, while 40% (n = 21) had impairment in the memory domain. Only 1 participant (1.89%) showed problems in the visuospatial and visuoconstructive domains. We observed that reduced cortical thickness in the left parahippocampal region (t(48) = 2.28, P = .03) and the right caudal-middle-frontal region (t(48) = 2.20, P = .03) was positively correlated with the memory domain.
Conclusions: Our findings suggest that cognitive impairment in individuals with the post-COVID-19 condition is associated with long-term alterations in the structure of the brain. These macrostructural changes may provide insight into the nature of cognitive symptoms.
. 2024 Apr 4.
doi: 10.3174/ajnr.A8167. Online ahead of print. Reduced Cortical Thickness Correlates of Cognitive Dysfunction in Post-COVID-19 Condition: Insights from a Long-Term Follow-up
Rosalia Dacosta-Aguayo[SUP] 1 2 [/SUP], Josep Puig[SUP] 3 4 [/SUP], Noemi Lamonja-Vicente[SUP] 1 5 [/SUP], Meritxell Carmona-Cervelló[SUP] 1 [/SUP], Brenda Biaani León-Gómez[SUP] 1 [/SUP], Gemma Monté-Rubio[SUP] 3 [/SUP], Victor M López-Linfante[SUP] 1 5 6 7 [/SUP], Valeria Zamora-Putin[SUP] 1 6 [/SUP], Pilar Montero-Alia[SUP] 1 5 [/SUP], Carla Chacon[SUP] 1 8 [/SUP], Jofre Bielsa[SUP] 1 [/SUP], Eduard Moreno-Gabriel[SUP] 1 5 9 [/SUP], Rosa Garcia-Sierra[SUP] 1 5 10 [/SUP], Alba Pachón[SUP] 1 [/SUP], Anna Costa[SUP] 1 [/SUP], Maria Mataró[SUP] 2 [/SUP], Julia G Prado[SUP] 11 12 13 [/SUP], Eva Martinez-Cáceres[SUP] 7 13 14 15 [/SUP], Lourdes Mateu[SUP] 12 13 16 17 [/SUP], Marta Massanella[SUP] 11 12 13 17 [/SUP], Concepción Violán[SUP] 18 8 13 19 20 [/SUP], Pere Torán-Monserrat[SUP] 1 5 13 21 [/SUP]; Aliança ProHEpiC-19 Cognitiu (The APC Collaborative Group)
Affiliations
- PMID: 38575319
- DOI: 10.3174/ajnr.A8167
Background and purpose: There is a paucity of data on long-term neuroimaging findings from individuals who have developed the post-coronavirus 2019 (COVID-19) condition. Only 2 studies have investigated the correlations between cognitive assessment results and structural MR imaging in this population. This study aimed to elucidate the long-term cognitive outcomes of participants with the post-COVID-19 condition and to correlate these cognitive findings with structural MR imaging data in the post-COVID-19 condition.
Materials and methods: A cohort of 53 participants with the post-COVID-19 condition underwent 3T brain MR imaging with T1 and FLAIR sequences obtained a median of 1.8 years after Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infection. A comprehensive neuropsychological battery was used to assess several cognitive domains in the same individuals. Correlations between cognitive domains and whole-brain voxel-based morphometry were performed. Different ROIs from FreeSurfer were used to perform the same correlations with other neuroimaging features.
Results: According to the Frascati criteria, more than one-half of the participants had deficits in the attentional (55%, n = 29) and executive (59%, n = 31) domains, while 40% (n = 21) had impairment in the memory domain. Only 1 participant (1.89%) showed problems in the visuospatial and visuoconstructive domains. We observed that reduced cortical thickness in the left parahippocampal region (t(48) = 2.28, P = .03) and the right caudal-middle-frontal region (t(48) = 2.20, P = .03) was positively correlated with the memory domain.
Conclusions: Our findings suggest that cognitive impairment in individuals with the post-COVID-19 condition is associated with long-term alterations in the structure of the brain. These macrostructural changes may provide insight into the nature of cognitive symptoms.
