tetano
Editor, Senior Moderator
AJNR Am J Neuroradiol
. 2020 Jun 18.
doi: 10.3174/ajnr.A6651. Online ahead of print.
COVID-19 Neurologic Complication With CNS Vasculitis-Like Pattern
R Hanafi[SUP] 1 2 [/SUP], P-A Roger[SUP] 3 [/SUP], B Perin[SUP] 4 [/SUP], G Kuchcinski[SUP] 5 [/SUP], N Deleval[SUP] 6 [/SUP], F Dallery[SUP] 6 [/SUP], D Michel[SUP] 6 [/SUP], L Hacein-Bey[SUP] 7 [/SUP], J-P Pruvo[SUP] 5 [/SUP], O Outteryck[SUP] 5 [/SUP], J-M Constans[SUP] 6 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) is a viral infection caused by the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), which spreads rapidly from person to person and manifests in most symptomatic patients as a respiratory illness, similar to prior SARS viruses. Neurologic manifestations of COVID-19 are uncommon; those so far reported include encephalopathy, stroke from large-vessel occlusion, and polyneuropathy. We report a unique neurologic complication of COVID-19 in a patient who had extensive cerebral small-vessel ischemic lesions resembling cerebral vasculitis in a characteristic combined imaging pattern of ischemia, hemorrhage, and punctuate postcontrast enhancement. Also, a characteristic lower extremity skin rash was present in our patient. Our observation lends support to the increasingly suspected mechanism of "endotheliitis" associated with this novel coronavirus.
. 2020 Jun 18.
doi: 10.3174/ajnr.A6651. Online ahead of print.
COVID-19 Neurologic Complication With CNS Vasculitis-Like Pattern
R Hanafi[SUP] 1 2 [/SUP], P-A Roger[SUP] 3 [/SUP], B Perin[SUP] 4 [/SUP], G Kuchcinski[SUP] 5 [/SUP], N Deleval[SUP] 6 [/SUP], F Dallery[SUP] 6 [/SUP], D Michel[SUP] 6 [/SUP], L Hacein-Bey[SUP] 7 [/SUP], J-P Pruvo[SUP] 5 [/SUP], O Outteryck[SUP] 5 [/SUP], J-M Constans[SUP] 6 [/SUP]
Affiliations
- PMID: 32554425
- DOI: 10.3174/ajnr.A6651
Abstract
Coronavirus disease 2019 (COVID-19) is a viral infection caused by the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), which spreads rapidly from person to person and manifests in most symptomatic patients as a respiratory illness, similar to prior SARS viruses. Neurologic manifestations of COVID-19 are uncommon; those so far reported include encephalopathy, stroke from large-vessel occlusion, and polyneuropathy. We report a unique neurologic complication of COVID-19 in a patient who had extensive cerebral small-vessel ischemic lesions resembling cerebral vasculitis in a characteristic combined imaging pattern of ischemia, hemorrhage, and punctuate postcontrast enhancement. Also, a characteristic lower extremity skin rash was present in our patient. Our observation lends support to the increasingly suspected mechanism of "endotheliitis" associated with this novel coronavirus.