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AIDS . SARS-CoV-2 breakthrough infection among people with and without HIV in Ontario, Canada

tetano

Editor, Senior Moderator
AIDS


. 2026 Jan 1;40(1):119-122.
doi: 10.1097/QAD.0000000000004351. Epub 2025 Dec 4. SARS-CoV-2 breakthrough infection among people with and without HIV in Ontario, Canada

Cassandra Freitas[SUP] 1 2 [/SUP], Curtis L Cooper[SUP] 3 4 [/SUP], Abigail E Kroch[SUP] 1 [/SUP], Sarah A Buchan[SUP] 1 5 6 [/SUP], Rahim Moineddin[SUP] 1 7 [/SUP], Gordon Arbess[SUP] 7 8 [/SUP], Anita C Benoit[SUP] 1 9 10 [/SUP], Catharine Chambers[SUP] 1 5 [/SUP], Muluba Habanyama[SUP] 11 [/SUP], Claire E Kendall[SUP] 6 12 13 [/SUP], Jeffrey C Kwong[SUP] 1 5 6 7 14 [/SUP], Lawrence Mbuagbaw[SUP] 15 16 17 18 19 20 [/SUP], John McCullagh[SUP] 21 [/SUP], Nasheed Moqueet[SUP] 22 [/SUP], Devan Nambiar[SUP] 23 [/SUP], Vanessa Tran[SUP] 5 24 [/SUP], Sharon Walmsley[SUP] 14 [/SUP], Ann N Burchell[SUP] 1 2 7 [/SUP]; CHESS Study Team; Marc-André Langlois, Sergio Rueda, Anna Yeung, Ashley Mah, Samantha Lee, Aditi Patrikar, Darien Taylor



Affiliations
Abstract

We found that risk of SARS-CoV-2 breakthrough infection did not meaningfully differ between a population-based cohort of vaccinated people with HIV and a matched cohort of people without HIV after accounting for sociodemographic factors, previous SARS-CoV-2 infection, SARS-CoV-2 testing patterns and COVID-19 vaccine doses (14 December 2020 to 5 May 2024). However, rates of breakthrough infection were higher among men with HIV compared to without HIV during the pre-Omicron era.


 
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