Sharpe
Senior Moderator
Re: AHMEDABAD
Peripheral speculative post
If this does turn out to be bird flu, and the symptoms match too closely for comfort, one question that will have to be answered is the nature of the kidney damage. It is not one of those things that is talked about much in reports on H5N1 autopsies. We know that H5N1 can grow in the kidney--dog kidney cells are used to grow it for mammalian culture, but the nature of the damage is unclear to me. There was a tremendous amount of renal failure in soldiers during World War I, but they were all attributed to other things, not to Spanish Flu. If I get a chance tomorrow, I'm going to take a look again at the old literature to see if I can find out anything more. There are several possibilities for the renal damage that these patients are experiencing. One is that blood pressure drops very fast--as a result of internal hemorrhage, myocardial damage, shock, and this causes ischemic kidney damage. A second possibility is that the virus itself damages the kidney. The third possibility is that the hospitals are overprescribing drugs to these patients--which is a distinct possibility in the face of a severe viral infection. The fourth possibility is that a severe increase in cytokines and antibodies is damaging it. Anyway, whether bird flu or not, this is a very critical area to continue watching.
Peripheral speculative post
If this does turn out to be bird flu, and the symptoms match too closely for comfort, one question that will have to be answered is the nature of the kidney damage. It is not one of those things that is talked about much in reports on H5N1 autopsies. We know that H5N1 can grow in the kidney--dog kidney cells are used to grow it for mammalian culture, but the nature of the damage is unclear to me. There was a tremendous amount of renal failure in soldiers during World War I, but they were all attributed to other things, not to Spanish Flu. If I get a chance tomorrow, I'm going to take a look again at the old literature to see if I can find out anything more. There are several possibilities for the renal damage that these patients are experiencing. One is that blood pressure drops very fast--as a result of internal hemorrhage, myocardial damage, shock, and this causes ischemic kidney damage. A second possibility is that the virus itself damages the kidney. The third possibility is that the hospitals are overprescribing drugs to these patients--which is a distinct possibility in the face of a severe viral infection. The fourth possibility is that a severe increase in cytokines and antibodies is damaging it. Anyway, whether bird flu or not, this is a very critical area to continue watching.