tetano
Editor, Senior Moderator
Aging Dis
. 2020 May 9;11(3):465-469.
doi: 10.14336/AD.2020.0422. eCollection 2020 May.
Adipose Stem Cells (ASCs) and Stromal Vascular Fraction (SVF) as a Potential Therapy in Combating (COVID-19)-Disease
Pietro Gentile[SUP] 1 [/SUP], Aris Sterodimas[SUP] 2 [/SUP]
Affiliations
Abstract
A recent and interesting study reported improved respiratory activity after intravenous administration of mesenchymal stem cells (MSCs) into patients affected by coronavirus disease 2019 (COVID-19). These outcomes displayed that intravenous infiltration of MSCs is a safe and efficacy treatment for COVID-19 pneumonia, a severe acute respiratory illness caused by the coronavirus 2 (SARS-CoV-2). Only 7 patients were treated, but with extraordinary results, opening a new strategy in COVID-19 therapy. Currently, no specific therapies against SARS-CoV-2 are available. The MSCs therapy outcomes reported, are striking, as these cells inhibit the over-activation of the immune system, promoting endogenous repair, by improving the lung microenvironment after the SARS-CoV-2 infection. The MSCs could represent an effective, autologous and safe therapy, and therefore, sharing these published results, here is reported the potential use possibilities in COVID-19 of the most common MSCs represented by Adipose Stem Cells (ASCs).
Keywords: Adipocyte secreted exosomal microRNA; Covid-19; adipose derived stem cells; coronavirus; mesenchymal stem cells.
. 2020 May 9;11(3):465-469.
doi: 10.14336/AD.2020.0422. eCollection 2020 May.
Adipose Stem Cells (ASCs) and Stromal Vascular Fraction (SVF) as a Potential Therapy in Combating (COVID-19)-Disease
Pietro Gentile[SUP] 1 [/SUP], Aris Sterodimas[SUP] 2 [/SUP]
Affiliations
- PMID: 32489692
- PMCID: PMC7220297
- DOI: 10.14336/AD.2020.0422
Abstract
A recent and interesting study reported improved respiratory activity after intravenous administration of mesenchymal stem cells (MSCs) into patients affected by coronavirus disease 2019 (COVID-19). These outcomes displayed that intravenous infiltration of MSCs is a safe and efficacy treatment for COVID-19 pneumonia, a severe acute respiratory illness caused by the coronavirus 2 (SARS-CoV-2). Only 7 patients were treated, but with extraordinary results, opening a new strategy in COVID-19 therapy. Currently, no specific therapies against SARS-CoV-2 are available. The MSCs therapy outcomes reported, are striking, as these cells inhibit the over-activation of the immune system, promoting endogenous repair, by improving the lung microenvironment after the SARS-CoV-2 infection. The MSCs could represent an effective, autologous and safe therapy, and therefore, sharing these published results, here is reported the potential use possibilities in COVID-19 of the most common MSCs represented by Adipose Stem Cells (ASCs).
Keywords: Adipocyte secreted exosomal microRNA; Covid-19; adipose derived stem cells; coronavirus; mesenchymal stem cells.