tetano
Editor, Senior Moderator
Aging (Albany NY)
. 2022 Jan 31;14(undefined).
doi: 10.18632/aging.203863. Online ahead of print.
The effect of age on ventilation management and clinical outcomes in critically ill COVID-19 patients--insights from the PRoVENT-COVID study
Liselotte Hol[SUP] 1 [/SUP], Paula Van Oosten[SUP] 2 [/SUP], Sunny Nijbroek[SUP] 1 [/SUP], Anissa Tsonas[SUP] 2 [/SUP], Michela Botta[SUP] 2 [/SUP], Ary Serpa Neto[SUP] 2 3 4 [/SUP], Frederique Paulus[SUP] 2 5 [/SUP], Marcus Schultz[SUP] 2 6 7 [/SUP], PRoVENT–COVID; Collaborative group
Affiliations
Abstract
Introduction: We analyzed the association of age with ventilation practice and outcomes in critically ill COVID-19 patients requiring invasive ventilation.
Methods: Posthoc analysis of the PRoVENT-COVID study, an observational study performed in 22 ICUs in the first 3 months of the national outbreak in the Netherlands. The coprimary endpoint was a set of ventilator parameters, including tidal volume normalized for predicted bodyweight, positive end-expiratory pressure, driving pressure, and respiratory system compliance in the first 4 days of invasive ventilation. Secondary endpoints were other ventilation parameters, the use of rescue therapies, pulmonary and extrapulmonary complications in the first 28 days in the ICU, hospital- and ICU stay, and mortality.
Results: 1122 patients were divided into four groups based on age quartiles. No meaningful differences were found in ventilation parameters and in the use of rescue therapies for refractory hypoxemia in the first 4 days of invasive ventilation. Older patients received more often a tracheostomy, developed more frequently acute kidney injury and myocardial infarction, stayed longer in hospital and ICU, and had a higher mortality.
Conclusions: In this cohort of invasively ventilated critically ill COVID-19 patients, age had no effect on ventilator management. Higher age was associated with more complications, longer length of stay in ICU and hospital and a higher mortality.
Keywords: COVID-19; age; coronavirus disease 2019; critical care; invasive ventilation; mortality.
. 2022 Jan 31;14(undefined).
doi: 10.18632/aging.203863. Online ahead of print.
The effect of age on ventilation management and clinical outcomes in critically ill COVID-19 patients--insights from the PRoVENT-COVID study
Liselotte Hol[SUP] 1 [/SUP], Paula Van Oosten[SUP] 2 [/SUP], Sunny Nijbroek[SUP] 1 [/SUP], Anissa Tsonas[SUP] 2 [/SUP], Michela Botta[SUP] 2 [/SUP], Ary Serpa Neto[SUP] 2 3 4 [/SUP], Frederique Paulus[SUP] 2 5 [/SUP], Marcus Schultz[SUP] 2 6 7 [/SUP], PRoVENT–COVID; Collaborative group
Affiliations
- PMID: 35100136
- DOI: 10.18632/aging.203863
Abstract
Introduction: We analyzed the association of age with ventilation practice and outcomes in critically ill COVID-19 patients requiring invasive ventilation.
Methods: Posthoc analysis of the PRoVENT-COVID study, an observational study performed in 22 ICUs in the first 3 months of the national outbreak in the Netherlands. The coprimary endpoint was a set of ventilator parameters, including tidal volume normalized for predicted bodyweight, positive end-expiratory pressure, driving pressure, and respiratory system compliance in the first 4 days of invasive ventilation. Secondary endpoints were other ventilation parameters, the use of rescue therapies, pulmonary and extrapulmonary complications in the first 28 days in the ICU, hospital- and ICU stay, and mortality.
Results: 1122 patients were divided into four groups based on age quartiles. No meaningful differences were found in ventilation parameters and in the use of rescue therapies for refractory hypoxemia in the first 4 days of invasive ventilation. Older patients received more often a tracheostomy, developed more frequently acute kidney injury and myocardial infarction, stayed longer in hospital and ICU, and had a higher mortality.
Conclusions: In this cohort of invasively ventilated critically ill COVID-19 patients, age had no effect on ventilator management. Higher age was associated with more complications, longer length of stay in ICU and hospital and a higher mortality.
Keywords: COVID-19; age; coronavirus disease 2019; critical care; invasive ventilation; mortality.