tetano
Editor, Senior Moderator
Aging (Albany NY)
. 2021 Mar 19;13.
doi: 10.18632/aging.202733. Online ahead of print.
Sex-specific differences of humoral immunity and transcriptome diversification in older adults vaccinated with inactivated quadrivalent influenza vaccines
Jing Yang[SUP] 1 2 [/SUP], Xiaoyuan Huang[SUP] 1 2 [/SUP], Jiayou Zhang[SUP] 1 2 [/SUP], Renfeng Fan[SUP] 3 [/SUP], Wei Zhao[SUP] 1 2 [/SUP], Tian Han[SUP] 1 2 [/SUP], Kai Duan[SUP] 1 2 [/SUP], Xinguo Li[SUP] 1 2 [/SUP], Peiyu Zeng[SUP] 4 [/SUP], Jinglong Deng[SUP] 4 [/SUP], Jikai Zhang[SUP] 3 [/SUP], Xiaoming Yang[SUP] 1 5 [/SUP]
Affiliations
Abstract
Clinical data showed sex variability in the immune response to influenza vaccination, this study aimed to investigate differentially expressed genes (DEGs) that contribute to sex-bias immunity to quadrivalent inactivated influenza vaccines (QIVs) in the elderly. 60 healthy adults aged 60-80 yrs were vaccinated with QIVs, and gene expression was analyzed before and after vaccination. The humoral immunity was analyzed by HAI assay, and the correlation of gene expression patterns of two sex groups with humoral immunity was analyzed. The DEGs involved in type I interferon signaling pathway and complement activation of classical pathway were upregulated within 3 days in females. At Day 28, the immune response showed a male-bias pattern associated with the regulation of protein processing and complement activation of classical pathway. A list of DEGs associated with variant responses to influenza vaccination between females and males were identified by biology-driven clustering. Old females have a greater immune response to QIVs but a rapid antibody decline, while old males have the advantages to sustain a durable response. In addition, we identified genes that may contribute to the sex variations toward influenza vaccination in the aged. Our findings highlight the importance of developing personalized seasonal influenza vaccines.
Keywords: DEGs (differential expressed genes); HAI; QIVs (quadrivalent inactivated influenza vaccines); sex dimorphism; transcripts.
. 2021 Mar 19;13.
doi: 10.18632/aging.202733. Online ahead of print.
Sex-specific differences of humoral immunity and transcriptome diversification in older adults vaccinated with inactivated quadrivalent influenza vaccines
Jing Yang[SUP] 1 2 [/SUP], Xiaoyuan Huang[SUP] 1 2 [/SUP], Jiayou Zhang[SUP] 1 2 [/SUP], Renfeng Fan[SUP] 3 [/SUP], Wei Zhao[SUP] 1 2 [/SUP], Tian Han[SUP] 1 2 [/SUP], Kai Duan[SUP] 1 2 [/SUP], Xinguo Li[SUP] 1 2 [/SUP], Peiyu Zeng[SUP] 4 [/SUP], Jinglong Deng[SUP] 4 [/SUP], Jikai Zhang[SUP] 3 [/SUP], Xiaoming Yang[SUP] 1 5 [/SUP]
Affiliations
- PMID: 33744852
- DOI: 10.18632/aging.202733
Abstract
Clinical data showed sex variability in the immune response to influenza vaccination, this study aimed to investigate differentially expressed genes (DEGs) that contribute to sex-bias immunity to quadrivalent inactivated influenza vaccines (QIVs) in the elderly. 60 healthy adults aged 60-80 yrs were vaccinated with QIVs, and gene expression was analyzed before and after vaccination. The humoral immunity was analyzed by HAI assay, and the correlation of gene expression patterns of two sex groups with humoral immunity was analyzed. The DEGs involved in type I interferon signaling pathway and complement activation of classical pathway were upregulated within 3 days in females. At Day 28, the immune response showed a male-bias pattern associated with the regulation of protein processing and complement activation of classical pathway. A list of DEGs associated with variant responses to influenza vaccination between females and males were identified by biology-driven clustering. Old females have a greater immune response to QIVs but a rapid antibody decline, while old males have the advantages to sustain a durable response. In addition, we identified genes that may contribute to the sex variations toward influenza vaccination in the aged. Our findings highlight the importance of developing personalized seasonal influenza vaccines.
Keywords: DEGs (differential expressed genes); HAI; QIVs (quadrivalent inactivated influenza vaccines); sex dimorphism; transcripts.