tetano
Editor, Senior Moderator
Aging (Albany NY)
. 2021 Jan 10;12.
doi: 10.18632/aging.202375. Online ahead of print.
Lung adenocarcinoma patients have higher risk of SARS-CoV-2 infection
Long Chen[SUP] 1 [/SUP], Yue Liu[SUP] 1 [/SUP], Jiamin Wu[SUP] 2 [/SUP], Chao Deng[SUP] 3 [/SUP], Jianjun Tan[SUP] 3 [/SUP], Huawen Liu[SUP] 3 [/SUP], Li Zhong[SUP] 1 [/SUP]
Affiliations
Abstract
Both lung adenocarcinoma and coronavirus disease 2019 would cause pulmonary inflammation. Angiotensin-converting enzyme 2, the functional receptor of SARS-CoV-2, also plays a key role in lung adenocarcinoma. To study the risk of SARS-CoV-2 infection in lung adenocarcinoma patients, mRNA and microRNA profiles were obtained from The Cancer Genome Atlas and Gene Expression Omnibus followed by bioinformatics analysis. A network which regards angiotensin-converting enzyme 2 as the center was structured. In addition, via immunological analysis to explore the essential mechanism of SARS-CoV-2 susceptibility in lung adenocarcinoma. Compared with normal tissue, angiotensin-converting enzyme 2 was increased in lung adenocarcinoma patients. Furthermore, a total of 7 correlated differently expressed mRNAs (ACE2, CXCL9, MMP12, IL6, AZU1, FCN3, HYAL1 and IRAK3) and 5 correlated differently expressed microRNAs (miR-125b-5p, miR-9-5p, miR-130b-5p, miR-381-3p and miR-421) were screened. Interestingly, the most frequent toll-like receptor signaling pathway was enriched by mRNA (interlukin 6) and miRNA (miR-125b-5p) sets simultaneously. In conclusion, it was assumed that miR-125b-5p-ACE2-IL6 axis could alter the risk of SARS-CoV-2 infection in lung adenocarcinoma patients.
Keywords: ACE2; COVID-19; IL6; SARS-CoV-2; lung adenocarcinoma; miR-125b-5p.
. 2021 Jan 10;12.
doi: 10.18632/aging.202375. Online ahead of print.
Lung adenocarcinoma patients have higher risk of SARS-CoV-2 infection
Long Chen[SUP] 1 [/SUP], Yue Liu[SUP] 1 [/SUP], Jiamin Wu[SUP] 2 [/SUP], Chao Deng[SUP] 3 [/SUP], Jianjun Tan[SUP] 3 [/SUP], Huawen Liu[SUP] 3 [/SUP], Li Zhong[SUP] 1 [/SUP]
Affiliations
- PMID: 33429366
- DOI: 10.18632/aging.202375
Abstract
Both lung adenocarcinoma and coronavirus disease 2019 would cause pulmonary inflammation. Angiotensin-converting enzyme 2, the functional receptor of SARS-CoV-2, also plays a key role in lung adenocarcinoma. To study the risk of SARS-CoV-2 infection in lung adenocarcinoma patients, mRNA and microRNA profiles were obtained from The Cancer Genome Atlas and Gene Expression Omnibus followed by bioinformatics analysis. A network which regards angiotensin-converting enzyme 2 as the center was structured. In addition, via immunological analysis to explore the essential mechanism of SARS-CoV-2 susceptibility in lung adenocarcinoma. Compared with normal tissue, angiotensin-converting enzyme 2 was increased in lung adenocarcinoma patients. Furthermore, a total of 7 correlated differently expressed mRNAs (ACE2, CXCL9, MMP12, IL6, AZU1, FCN3, HYAL1 and IRAK3) and 5 correlated differently expressed microRNAs (miR-125b-5p, miR-9-5p, miR-130b-5p, miR-381-3p and miR-421) were screened. Interestingly, the most frequent toll-like receptor signaling pathway was enriched by mRNA (interlukin 6) and miRNA (miR-125b-5p) sets simultaneously. In conclusion, it was assumed that miR-125b-5p-ACE2-IL6 axis could alter the risk of SARS-CoV-2 infection in lung adenocarcinoma patients.
Keywords: ACE2; COVID-19; IL6; SARS-CoV-2; lung adenocarcinoma; miR-125b-5p.