tetano
Editor, Senior Moderator
Aging (Albany NY)
. 2020 Nov 24;12.
doi: 10.18632/aging.104138. Online ahead of print.
Coagulopathy in patients with COVID-19: a systematic review and meta-analysis
Xiaolin Zhang[SUP] 1 [/SUP], Xue Yang[SUP] 1 [/SUP], Hongmei Jiao[SUP] 1 [/SUP], Xinmin Liu[SUP] 1 [/SUP]
Affiliations
Abstract
COVID-19 patients frequently exhibit coagulation abnormalities and thrombotic events. In this meta-analysis, we investigated the association between coagulopathy and the severity of COVID-19 illness. Using PubMed, Embase, Cochrane, WanFang Database, CNKI, and medRxiv, a systematic literature search was conducted for studies published between December 1, 2019 and May 1, 2020. We then analyzed coagulation parameters in COVID-19 patients exhibiting less severe and more severe symptoms. All statistical analyses were performed using Stata14.0 software. A total of 3,952 confirmed COVID-19 patients from 25 studies were included in the meta-analysis. Patients with severe symptoms exhibited higher levels of D-dimer, prothrombin time (PT), and fibrinogen (FIB) than patients with less severe symptoms (SMD 0.83, 95% CI: 0.70-0.97, I[SUP]2[/SUP] 56.9%; SMD 0.39, 95% CI: 0.14-0.64, I[SUP]2[/SUP] 79.4%; and SMD 0.35, 95% CI: 0.17-0.53, I[SUP]2[/SUP] 42.4%, respectively). However, platelet and activated partial thromboplastin times did not differ (SMD -0.26, 95% CI: -0.56-0.05, I[SUP]2[/SUP] 82.2%; and SMD -0.14, 95% CI: -0.45-0.18, I[SUP]2[/SUP] 75.7%, respectively). These findings demonstrate that hypercoagulable coagulopathy is associated with the severity of COVID-19 symptoms and that D-dimer, PT, and FIB values are the main parameters that should be considered when evaluating coagulopathy in COVID-19 patients.
Keywords: COVID-19; Coronavirus; coagulation; coagulopathy; disease severity.
. 2020 Nov 24;12.
doi: 10.18632/aging.104138. Online ahead of print.
Coagulopathy in patients with COVID-19: a systematic review and meta-analysis
Xiaolin Zhang[SUP] 1 [/SUP], Xue Yang[SUP] 1 [/SUP], Hongmei Jiao[SUP] 1 [/SUP], Xinmin Liu[SUP] 1 [/SUP]
Affiliations
- PMID: 33229625
- DOI: 10.18632/aging.104138
Abstract
COVID-19 patients frequently exhibit coagulation abnormalities and thrombotic events. In this meta-analysis, we investigated the association between coagulopathy and the severity of COVID-19 illness. Using PubMed, Embase, Cochrane, WanFang Database, CNKI, and medRxiv, a systematic literature search was conducted for studies published between December 1, 2019 and May 1, 2020. We then analyzed coagulation parameters in COVID-19 patients exhibiting less severe and more severe symptoms. All statistical analyses were performed using Stata14.0 software. A total of 3,952 confirmed COVID-19 patients from 25 studies were included in the meta-analysis. Patients with severe symptoms exhibited higher levels of D-dimer, prothrombin time (PT), and fibrinogen (FIB) than patients with less severe symptoms (SMD 0.83, 95% CI: 0.70-0.97, I[SUP]2[/SUP] 56.9%; SMD 0.39, 95% CI: 0.14-0.64, I[SUP]2[/SUP] 79.4%; and SMD 0.35, 95% CI: 0.17-0.53, I[SUP]2[/SUP] 42.4%, respectively). However, platelet and activated partial thromboplastin times did not differ (SMD -0.26, 95% CI: -0.56-0.05, I[SUP]2[/SUP] 82.2%; and SMD -0.14, 95% CI: -0.45-0.18, I[SUP]2[/SUP] 75.7%, respectively). These findings demonstrate that hypercoagulable coagulopathy is associated with the severity of COVID-19 symptoms and that D-dimer, PT, and FIB values are the main parameters that should be considered when evaluating coagulopathy in COVID-19 patients.
Keywords: COVID-19; Coronavirus; coagulation; coagulopathy; disease severity.