The study is one of the first to examine vitamin D and breast cancer progression.
Low vitamin D levels among women with breast cancer correlate with more aggressive tumors and poorer prognosis, according to a new University of Rochester Medical Center...
The URMC epidemiology study associates sub-optimal (less than 32 mg/ml) vitamin D levels with poor scores on every major biological marker that helps physicians predict a patient’s breast cancer outcome.
A statistical analysis showed that cancers known to be more aggressive, such as triple-negative tumors (they do not express estrogen, progesterone, or HER2 human epidermal growth factor receptor 2), correlated with low vitamin D levels. Triple-negative cancers are often associated with younger women and minority women, and Peppone’s study also found that both premenopausal women and black women tended to have sub-optimal vitamin D levels, compared to older, Caucasian women.
In addition, a strong inverse correlation was found between decreasing vitamin D levels and increasing Oncotype scores. And finally, patients with invasive cancer, versus women with in-situ or stage 0 disease, also were more likely to have sub-optimal vitamin D levels.
Full article and related articles:
http://www.urmc.rochester.edu/news/story/index.cfm?id=3182
Low vitamin D levels among women with breast cancer correlate with more aggressive tumors and poorer prognosis, according to a new University of Rochester Medical Center...
The URMC epidemiology study associates sub-optimal (less than 32 mg/ml) vitamin D levels with poor scores on every major biological marker that helps physicians predict a patient’s breast cancer outcome.
A statistical analysis showed that cancers known to be more aggressive, such as triple-negative tumors (they do not express estrogen, progesterone, or HER2 human epidermal growth factor receptor 2), correlated with low vitamin D levels. Triple-negative cancers are often associated with younger women and minority women, and Peppone’s study also found that both premenopausal women and black women tended to have sub-optimal vitamin D levels, compared to older, Caucasian women.
In addition, a strong inverse correlation was found between decreasing vitamin D levels and increasing Oncotype scores. And finally, patients with invasive cancer, versus women with in-situ or stage 0 disease, also were more likely to have sub-optimal vitamin D levels.
Full article and related articles:
http://www.urmc.rochester.edu/news/story/index.cfm?id=3182