tetano
Editor, Senior Moderator
Clin Vaccine Immunol. 2016 Mar 30. pii: CVI.00563-15. [Epub ahead of print]
[h=1]Age at vaccination and timing of infection do not alter vaccine-associated enhanced respiratory disease in influenza A virus infected pigs.[/h] Souza CK[SUP]1[/SUP], Raj?o DS[SUP]2[/SUP], Loving CL[SUP]2[/SUP], Gauger PC[SUP]3[/SUP], P?rez DR[SUP]4[/SUP], Vincent AL[SUP]5[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Whole inactivated virus (WIV) vaccines are widely used in the swine industry to reduce clinical disease against homologous influenza A virus (IAV) infection. In pigs experimentally challenged with antigenically distinct heterologous IAV of the same hemagglutinin subtype, WIV vaccinates have been shown to develop vaccine-associated enhanced respiratory disease (VAERD). We evaluated the impact of vaccine valency, age at vaccination, and duration between vaccination and challenge on development of VAERD using vaccine containing δ1-H1N2 and challenge with pandemic H1N1 (pH1N1) virus. Pigs were vaccinated with monovalent WIV MN08 (δ1-H1N2) and bivalent (δ1-H1N2/H3N2) or (δ1-H1N2/pH1N1) vaccines then were challenged with pH1N1 at 3 weeks post-boost (wpb). Another group was vaccinated with the same monovalent WIV followed by challenge at 6 wpb to determine if time post-vaccination plays a role in development of VAERD. In a follow up study, the impact of age of first WIV vaccination (4 versus 9 weeks of age) with a boost three weeks later (7 versus 12 weeks of age) was evaluated. A monovalent live-attenuated influenza virus (LAIV) vaccine administered at 4 and 7 weeks of age was also included. All mismatched WIV groups had significantly higher lung lesions compared to LAIV, bivalent MN08-CA09 and controls groups. Age of first vaccination or length of time between booster dose and subsequent challenge did not alter the development of VAERD in WIV vaccinated pigs. Importantly, the mismatched component of the bivalent MN08-CA09 WIV did not override the protective effect of the matched vaccine component.
Copyright ? 2016, American Society for Microbiology. All Rights Reserved.
PMID: 27030585 [PubMed - as supplied by publisher]
[h=1]Age at vaccination and timing of infection do not alter vaccine-associated enhanced respiratory disease in influenza A virus infected pigs.[/h] Souza CK[SUP]1[/SUP], Raj?o DS[SUP]2[/SUP], Loving CL[SUP]2[/SUP], Gauger PC[SUP]3[/SUP], P?rez DR[SUP]4[/SUP], Vincent AL[SUP]5[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Whole inactivated virus (WIV) vaccines are widely used in the swine industry to reduce clinical disease against homologous influenza A virus (IAV) infection. In pigs experimentally challenged with antigenically distinct heterologous IAV of the same hemagglutinin subtype, WIV vaccinates have been shown to develop vaccine-associated enhanced respiratory disease (VAERD). We evaluated the impact of vaccine valency, age at vaccination, and duration between vaccination and challenge on development of VAERD using vaccine containing δ1-H1N2 and challenge with pandemic H1N1 (pH1N1) virus. Pigs were vaccinated with monovalent WIV MN08 (δ1-H1N2) and bivalent (δ1-H1N2/H3N2) or (δ1-H1N2/pH1N1) vaccines then were challenged with pH1N1 at 3 weeks post-boost (wpb). Another group was vaccinated with the same monovalent WIV followed by challenge at 6 wpb to determine if time post-vaccination plays a role in development of VAERD. In a follow up study, the impact of age of first WIV vaccination (4 versus 9 weeks of age) with a boost three weeks later (7 versus 12 weeks of age) was evaluated. A monovalent live-attenuated influenza virus (LAIV) vaccine administered at 4 and 7 weeks of age was also included. All mismatched WIV groups had significantly higher lung lesions compared to LAIV, bivalent MN08-CA09 and controls groups. Age of first vaccination or length of time between booster dose and subsequent challenge did not alter the development of VAERD in WIV vaccinated pigs. Importantly, the mismatched component of the bivalent MN08-CA09 WIV did not override the protective effect of the matched vaccine component.
Copyright ? 2016, American Society for Microbiology. All Rights Reserved.
PMID: 27030585 [PubMed - as supplied by publisher]