tetano
Editor, Senior Moderator
Age Ageing
. 2025 Jul 1;54(7):afaf169.
doi: 10.1093/ageing/afaf169. Influenza vaccination and risk of dementia: a systematic review and meta-analysis
Wen-Kang Yang[SUP] 1 2 [/SUP], Shih-Chieh Shao[SUP] 3 4 [/SUP], Chia-Chao Liu[SUP] 3 [/SUP], Ching-Chi Chi[SUP] 5 6 [/SUP]
Affiliations
Background: The association between influenza vaccination and a reduction in dementia was unclear with inconsistent evidence. We aimed to evaluate the association between influenza vaccination and dementia risk in the overall population and the high-risk populations for dementia, such as patients with chronic kidney syndrome (CKD), chronic obstruction pulmonary disease (COPD) and vascular disease.
Methods: We performed a systematic review and searched PubMed, Embase and CENTRAL from inception to 6 April 2025. The risk of bias was assessed using the Newcastle-Ottawa Scale. A random-effects model meta-analysis was executed.
Results: We included eight cohort studies with 9,938,696 subjects. Except for one study, the risk of bias of all other included studies was low. Influenza vaccination was associated with a reduced risk of incident dementia in high-risk populations for dementia, but not in the overall population (HR 0.93; 95% CI: 0.86-1.01). For high-risk populations, more than one dose of influenza vaccination showed an association with a lower risk of incident dementia (2-3 doses: HR 0.84; 95% CI: 0.76-0.92; ≥ 4 doses: HR 0.43; 95% CI: 0.38-0.48).
Conclusion: Influenza vaccination was associated with a decreasing risk of incident dementia in a dose-response manner.
Keywords: Alzheimer disease; aged; dementia; influenza vaccination; meta-analysis; older people; systematic review.
. 2025 Jul 1;54(7):afaf169.
doi: 10.1093/ageing/afaf169. Influenza vaccination and risk of dementia: a systematic review and meta-analysis
Wen-Kang Yang[SUP] 1 2 [/SUP], Shih-Chieh Shao[SUP] 3 4 [/SUP], Chia-Chao Liu[SUP] 3 [/SUP], Ching-Chi Chi[SUP] 5 6 [/SUP]
Affiliations
- PMID: 40601364
- DOI: 10.1093/ageing/afaf169
Background: The association between influenza vaccination and a reduction in dementia was unclear with inconsistent evidence. We aimed to evaluate the association between influenza vaccination and dementia risk in the overall population and the high-risk populations for dementia, such as patients with chronic kidney syndrome (CKD), chronic obstruction pulmonary disease (COPD) and vascular disease.
Methods: We performed a systematic review and searched PubMed, Embase and CENTRAL from inception to 6 April 2025. The risk of bias was assessed using the Newcastle-Ottawa Scale. A random-effects model meta-analysis was executed.
Results: We included eight cohort studies with 9,938,696 subjects. Except for one study, the risk of bias of all other included studies was low. Influenza vaccination was associated with a reduced risk of incident dementia in high-risk populations for dementia, but not in the overall population (HR 0.93; 95% CI: 0.86-1.01). For high-risk populations, more than one dose of influenza vaccination showed an association with a lower risk of incident dementia (2-3 doses: HR 0.84; 95% CI: 0.76-0.92; ≥ 4 doses: HR 0.43; 95% CI: 0.38-0.48).
Conclusion: Influenza vaccination was associated with a decreasing risk of incident dementia in a dose-response manner.
Keywords: Alzheimer disease; aged; dementia; influenza vaccination; meta-analysis; older people; systematic review.