tetano
Editor, Senior Moderator
Adv Respir Med
. 2021 Dec 9.
doi: 10.5603/ARM.a2021.0098. Online ahead of print.
Fibrinogen-to-albumin ratio predicts mortality in COVID-19 patients admitted to the intensive care unit
Abdulmecit Afşin[SUP] 1 [/SUP], Hakan Tibilli[SUP] 2 [/SUP], Yusuf Hoşoğlu[SUP] 3 [/SUP], Ramazan Asoğlu[SUP] 3 [/SUP], Ahmet Süsenbük[SUP] 2 [/SUP], Sezer Markirt[SUP] 2 [/SUP], Verda Dinar Tuna[SUP] 4 [/SUP]
Affiliations
Abstract
Introduction: Coronavirus disease 2019 (COVID-19) is an inflammatory disease, and serum albumin and fibrinogen are two important factors in systemic inflammation. We aimed to investigate the relationship between the fibrinogen-to-albumin ratio (FAR) and in-hospital mortality in COVID-19 patients admitted to the intensive care unit (ICU).
Material and methods: Patients diagnosed with COVID-19 admitted to the Adiyaman Training and Research Hospital from August to November 2020 were enrolled in this retrospective cohort study. They were divided into 2 groups based on in-hospital mortality: a survivor group (n = 188) and a non-survivor group (n = 198). FAR was calculated by dividing the fibrinogen value by the albumin value. Mortality outcomes were followed up until December 15, 2020.
Results: The average age of the patients was 71.2 ± 12.9 years, and 54% were male. On multivariate logistic analysis, diabetes mellitus (OR: 1.806; 95% CI: 1.142-2.856; p = 0.011), troponin I levels (OR: 1.776; 95% CI: 1.031-3.061; p = 0.038), and FAR (OR: 1.004; 95% CI: 1.004-1.007; p = 0.010) at ICU admission were independent predictors of in-hospital mortality in patients with COVID-19.
Conclusions: The FAR at admission was associated with mortality in patients infected with SARS-CoV-2 in the ICU.
Keywords: coronavirus disease 2019; fibrinogen-to-albumin ratio; intensive care unit; mortality
. 2021 Dec 9.
doi: 10.5603/ARM.a2021.0098. Online ahead of print.
Fibrinogen-to-albumin ratio predicts mortality in COVID-19 patients admitted to the intensive care unit
Abdulmecit Afşin[SUP] 1 [/SUP], Hakan Tibilli[SUP] 2 [/SUP], Yusuf Hoşoğlu[SUP] 3 [/SUP], Ramazan Asoğlu[SUP] 3 [/SUP], Ahmet Süsenbük[SUP] 2 [/SUP], Sezer Markirt[SUP] 2 [/SUP], Verda Dinar Tuna[SUP] 4 [/SUP]
Affiliations
- PMID: 34881805
- DOI: 10.5603/ARM.a2021.0098
Abstract
Introduction: Coronavirus disease 2019 (COVID-19) is an inflammatory disease, and serum albumin and fibrinogen are two important factors in systemic inflammation. We aimed to investigate the relationship between the fibrinogen-to-albumin ratio (FAR) and in-hospital mortality in COVID-19 patients admitted to the intensive care unit (ICU).
Material and methods: Patients diagnosed with COVID-19 admitted to the Adiyaman Training and Research Hospital from August to November 2020 were enrolled in this retrospective cohort study. They were divided into 2 groups based on in-hospital mortality: a survivor group (n = 188) and a non-survivor group (n = 198). FAR was calculated by dividing the fibrinogen value by the albumin value. Mortality outcomes were followed up until December 15, 2020.
Results: The average age of the patients was 71.2 ± 12.9 years, and 54% were male. On multivariate logistic analysis, diabetes mellitus (OR: 1.806; 95% CI: 1.142-2.856; p = 0.011), troponin I levels (OR: 1.776; 95% CI: 1.031-3.061; p = 0.038), and FAR (OR: 1.004; 95% CI: 1.004-1.007; p = 0.010) at ICU admission were independent predictors of in-hospital mortality in patients with COVID-19.
Conclusions: The FAR at admission was associated with mortality in patients infected with SARS-CoV-2 in the ICU.
Keywords: coronavirus disease 2019; fibrinogen-to-albumin ratio; intensive care unit; mortality