tetano
Editor, Senior Moderator
Addiction
. 2022 Feb 7.
doi: 10.1111/add.15835. Online ahead of print.
Relationship between high-risk alcohol consumption and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroconversion: a prospective seroepidemiologic cohort study among American college students
Sina Kianersi[SUP] 1 [/SUP], Christina Ludema[SUP] 1 [/SUP], Jonathan T Macy[SUP] 2 [/SUP], Chen Chen[SUP] 1 [/SUP], Molly Rosenberg[SUP] 1 [/SUP]
Affiliations
Abstract
Aims: To estimate the associations between high-risk alcohol consumption and (1) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroconversion, (2) self-reported new SARS-CoV-2 infection, and (3) symptomatic COVID-19.
Design: Prospective cohort study SETTING: Indiana University Bloomington (IUB), Indiana, USA.
Participants: N=1,027 IUB undergraduate students (64% female), aged 18 years or older, residing in Monroe County, Indiana, and seronegative for SARS-CoV-2 at study baseline.
Measurements: Primary exposure was high-risk alcohol consumption measured with an AUDIT questionnaire score of 8 or more. Primary outcome was SARS-CoV-2 seroconversion since baseline, assessed with two SARS-CoV-2 antibody tests, at baseline (September 2020) and endline (November 2020). Secondary outcomes were a) self-reported new SARS-CoV-2 infection at the study endline and b) self-reported symptomatic COVID-19 at baseline.
Findings: Prevalence of high-risk alcohol consumption was 34%. In models adjusted for demographics, students with high-risk alcohol consumption status had 2.44 [95% confidence interval (CI): (1.35, 4.25)] times the risk of SARS-CoV-2 seroconversion and 1.82 [95% CI: (1.02, 3.22)] times the risk of self-reporting a positive SARS-CoV-2 infection, compared with students with no such risk. We did not identify any association between high-risk alcohol consumption and symptomatic COVID-19 [prevalence ratio (95% CI): 1.17 (0.93, 1.47)]. Findings from sensitivity analyses corroborated these results and suggested potential for a dose-response relationship.
Conclusions: Among American college students, high-risk alcohol consumption appears to be associated with higher risk for severe acute respiratory syndrome coronavirus 2 seroconversion/infection.
Keywords: AUDIT; AUDIT-C; American colleges; COVID-19; SARS-CoV-2; heavy drinking; high-risk alcohol consumption; quantity-frequency index; respiratory disease; young adults.
. 2022 Feb 7.
doi: 10.1111/add.15835. Online ahead of print.
Relationship between high-risk alcohol consumption and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroconversion: a prospective seroepidemiologic cohort study among American college students
Sina Kianersi[SUP] 1 [/SUP], Christina Ludema[SUP] 1 [/SUP], Jonathan T Macy[SUP] 2 [/SUP], Chen Chen[SUP] 1 [/SUP], Molly Rosenberg[SUP] 1 [/SUP]
Affiliations
- PMID: 35129232
- DOI: 10.1111/add.15835
Abstract
Aims: To estimate the associations between high-risk alcohol consumption and (1) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroconversion, (2) self-reported new SARS-CoV-2 infection, and (3) symptomatic COVID-19.
Design: Prospective cohort study SETTING: Indiana University Bloomington (IUB), Indiana, USA.
Participants: N=1,027 IUB undergraduate students (64% female), aged 18 years or older, residing in Monroe County, Indiana, and seronegative for SARS-CoV-2 at study baseline.
Measurements: Primary exposure was high-risk alcohol consumption measured with an AUDIT questionnaire score of 8 or more. Primary outcome was SARS-CoV-2 seroconversion since baseline, assessed with two SARS-CoV-2 antibody tests, at baseline (September 2020) and endline (November 2020). Secondary outcomes were a) self-reported new SARS-CoV-2 infection at the study endline and b) self-reported symptomatic COVID-19 at baseline.
Findings: Prevalence of high-risk alcohol consumption was 34%. In models adjusted for demographics, students with high-risk alcohol consumption status had 2.44 [95% confidence interval (CI): (1.35, 4.25)] times the risk of SARS-CoV-2 seroconversion and 1.82 [95% CI: (1.02, 3.22)] times the risk of self-reporting a positive SARS-CoV-2 infection, compared with students with no such risk. We did not identify any association between high-risk alcohol consumption and symptomatic COVID-19 [prevalence ratio (95% CI): 1.17 (0.93, 1.47)]. Findings from sensitivity analyses corroborated these results and suggested potential for a dose-response relationship.
Conclusions: Among American college students, high-risk alcohol consumption appears to be associated with higher risk for severe acute respiratory syndrome coronavirus 2 seroconversion/infection.
Keywords: AUDIT; AUDIT-C; American colleges; COVID-19; SARS-CoV-2; heavy drinking; high-risk alcohol consumption; quantity-frequency index; respiratory disease; young adults.