tetano
Editor, Senior Moderator
Ocul Immunol Inflamm. 2019 Nov 7:1-7. doi: 10.1080/09273948.2019.1681470. [Epub ahead of print] [h=1]Acute Macular Neuroretinopathy Associated with Acute Influenza Virus Infection.[/h]
Ashfaq I[SUP]1[/SUP], Vrahimi M[SUP]1[/SUP], Waugh S[SUP]2[/SUP], Soomro T[SUP]1[/SUP], Grinton ME[SUP]1[/SUP], Browning AC[SUP]1[/SUP].
[h=3]Author information[/h] 1 Ophthalmology Department, Newcastle Eye Centre, Newcastle upon Tyne, UK. 2 Virology Department, Freeman Hospital, Newcastle upon Tyne, UK.
[h=3]Abstract[/h] Purpose: To describe a prospective case series of patients with acute macular neuroretinopathy (AMN) associated with acute influenza virus infectionMethods: Patients who presented with acute macular neuroretinopathy associated with confirmed influenza virus infection were subject to a detailed clinical history, HLA typing and longitudinal ophthalmological and imaging examinations.Results: Four female patients aged 18 to 32 years were studied. They reported the onset of ocular symptoms between 2 and 5 days after the development of flu like symptoms. Three patients had confirmed acute influenza B infection, while the fourth had influenza A. OCT angiography only demonstrated abnormal choriocapillaris perfusion in 1 patient and early oral Oseltamivir treatment appeared not to affect the ophthalmic outcome in one patient.Conclusion: This is the first report of AMN associated with virologically confirmed acute influenza virus infection. Variation in HLA alleles do not appear to predispose patients to influenza associated AMN.
[h=4]KEYWORDS:[/h] AMN; HLA typing; Influenza; OCT
PMID: 31697568 DOI: 10.1080/09273948.2019.1681470
Ashfaq I[SUP]1[/SUP], Vrahimi M[SUP]1[/SUP], Waugh S[SUP]2[/SUP], Soomro T[SUP]1[/SUP], Grinton ME[SUP]1[/SUP], Browning AC[SUP]1[/SUP].
[h=3]Author information[/h] 1 Ophthalmology Department, Newcastle Eye Centre, Newcastle upon Tyne, UK. 2 Virology Department, Freeman Hospital, Newcastle upon Tyne, UK.
[h=3]Abstract[/h] Purpose: To describe a prospective case series of patients with acute macular neuroretinopathy (AMN) associated with acute influenza virus infectionMethods: Patients who presented with acute macular neuroretinopathy associated with confirmed influenza virus infection were subject to a detailed clinical history, HLA typing and longitudinal ophthalmological and imaging examinations.Results: Four female patients aged 18 to 32 years were studied. They reported the onset of ocular symptoms between 2 and 5 days after the development of flu like symptoms. Three patients had confirmed acute influenza B infection, while the fourth had influenza A. OCT angiography only demonstrated abnormal choriocapillaris perfusion in 1 patient and early oral Oseltamivir treatment appeared not to affect the ophthalmic outcome in one patient.Conclusion: This is the first report of AMN associated with virologically confirmed acute influenza virus infection. Variation in HLA alleles do not appear to predispose patients to influenza associated AMN.
[h=4]KEYWORDS:[/h] AMN; HLA typing; Influenza; OCT
PMID: 31697568 DOI: 10.1080/09273948.2019.1681470