tetano
Editor, Senior Moderator
Manish M. Sood, MD, FRCPC1, Claudio Rigatto, MD, FRCPC1, Ryan Zarychanski, MD, FRCPC2, Paul Komenda, MD, FRCPC1, Amy R. Sood, PharmD13, Joe Bueti, MD, FRCPC4, Martina Reslerova, MD, FRCPC1, Dan Roberts, MD, FRCPC14, Julie Mojica, MSc4, Anand Kumar, MD, FRCPC1Corresponding Author Informationemail address
Received 16 November 2009; accepted 5 January 2010. published online 22 March 2010.
Corrected Proof
Background
2009 pandemic influenza A(H1N1) has led to a global increase in severe respiratory illness. Little is known about kidney outcomes and dialytic requirements in critically ill patients infected with pandemic H1N1.
Study Design
Prospective observational study.
Setting & Participants
50 patients with pandemic H1N1 admitted to any of 7 intensive care units in Manitoba, Canada, were prospectively followed.
Outcome & Measurements
Outcomes were kidney injury and kidney failure defined using RIFLE (risk, injury, failure, loss, end-stage disease) criteria or need for dialysis therapy.
Results
The pandemic H1N1 group was composed of 50 critically ill patients with pandemic H1N1 with severe respiratory syndrome (47 confirmed cases, 3 probable). Kidney injury, kidney failure, and need for dialysis occurred in 66.7%, 66%, and 11% of patients, respectively. Mortality was 16%. Kidney failure was associated with increased death (OR, 11.29; 95% CI, 1.29-98.9), whereas the need for dialysis was associated with an increase in length of stay (RR, 2.38; 95% CI, 2.13-25.75).
Limitations
Small population studied from single Canadian province; thus, limited generalizability.
Conclusions
In critically ill patients with pandemic H1N1, kidney injury, kidney failure, and the need for dialysis are common and associated with an increase in mortality and length of intensive care unit stay.
http://www.ajkd.org/article/S0272-6386(10)00116-2/abstract
Received 16 November 2009; accepted 5 January 2010. published online 22 March 2010.
Corrected Proof
Background
2009 pandemic influenza A(H1N1) has led to a global increase in severe respiratory illness. Little is known about kidney outcomes and dialytic requirements in critically ill patients infected with pandemic H1N1.
Study Design
Prospective observational study.
Setting & Participants
50 patients with pandemic H1N1 admitted to any of 7 intensive care units in Manitoba, Canada, were prospectively followed.
Outcome & Measurements
Outcomes were kidney injury and kidney failure defined using RIFLE (risk, injury, failure, loss, end-stage disease) criteria or need for dialysis therapy.
Results
The pandemic H1N1 group was composed of 50 critically ill patients with pandemic H1N1 with severe respiratory syndrome (47 confirmed cases, 3 probable). Kidney injury, kidney failure, and need for dialysis occurred in 66.7%, 66%, and 11% of patients, respectively. Mortality was 16%. Kidney failure was associated with increased death (OR, 11.29; 95% CI, 1.29-98.9), whereas the need for dialysis was associated with an increase in length of stay (RR, 2.38; 95% CI, 2.13-25.75).
Limitations
Small population studied from single Canadian province; thus, limited generalizability.
Conclusions
In critically ill patients with pandemic H1N1, kidney injury, kidney failure, and the need for dialysis are common and associated with an increase in mortality and length of intensive care unit stay.
http://www.ajkd.org/article/S0272-6386(10)00116-2/abstract