tetano
Editor, Senior Moderator
Acute Crit Care
. 2024 Aug;39(3):359-368.
doi: 10.4266/acc.2023.01137. Epub 2024 Aug 22. Increased red cell distribution width predicts mortality in COVID-19 patients admitted to a Dutch intensive care unit
Anthony D Mompiere[SUP] 1 [/SUP], Jos L M L le Noble[SUP] 1 2 [/SUP], Manon Fleuren-Janssen[SUP] 1 [/SUP], Kelly Broen[SUP] 3 [/SUP], Frits van Osch[SUP] 4 5 [/SUP], Norbert Foudraine[SUP] 1 [/SUP]
Affiliations
Background: Abnormal red blood cell distribution width (RDW) is associated with poor cardiovascular, respiratory, and coronavirus disease 2019 (COVID-19) outcomes. However, whether RDW provides prognostic insights regarding COVID-19 patients admitted to the intensive care unit (ICU) was unknown. Here, we retrospectively investigated the association of RDW with 30-day and 90- day mortalities, duration of mechanical ventilation, and length of ICU and hospital stay in patients with COVID-19.
Methods: This study included 321 patients with COVID-19 aged >18 years who were admitted to the ICU between March 2020 and July 2022. The outcomes were mortality, duration of mechanical ventilation, and length of stay. RDW >14.5% was assessed in blood samples within 24 hours of admission.
Results: The mortality rate was 30.5%. Multivariable Cox regression analysis showed an association between increased RDW and 30-day mortality (hazard ratio
, 3.64; 95% CI, 1.54-8.65), 90-day mortality (HR, 3.66; 95% CI, 1.59-8.40), and shorter duration of invasive ventilation (2.7 ventilator-free days, P=0.033).
Conclusions: Increased RDW in COVID-19 patients at ICU admission was associated with increased 30-day and 90-day mortalities, and shorter duration of invasive ventilation. Thus, RDW can be used as a surrogate biomarker for clinical outcomes in COVID-19 patients admitted to the ICU.
Keywords: COVID-19; biomarkers; length of stay; mortality; red cell distribution width.
. 2024 Aug;39(3):359-368.
doi: 10.4266/acc.2023.01137. Epub 2024 Aug 22. Increased red cell distribution width predicts mortality in COVID-19 patients admitted to a Dutch intensive care unit
Anthony D Mompiere[SUP] 1 [/SUP], Jos L M L le Noble[SUP] 1 2 [/SUP], Manon Fleuren-Janssen[SUP] 1 [/SUP], Kelly Broen[SUP] 3 [/SUP], Frits van Osch[SUP] 4 5 [/SUP], Norbert Foudraine[SUP] 1 [/SUP]
Affiliations
- PMID: 39266271
- PMCID: PMC11392698
- DOI: 10.4266/acc.2023.01137
Background: Abnormal red blood cell distribution width (RDW) is associated with poor cardiovascular, respiratory, and coronavirus disease 2019 (COVID-19) outcomes. However, whether RDW provides prognostic insights regarding COVID-19 patients admitted to the intensive care unit (ICU) was unknown. Here, we retrospectively investigated the association of RDW with 30-day and 90- day mortalities, duration of mechanical ventilation, and length of ICU and hospital stay in patients with COVID-19.
Methods: This study included 321 patients with COVID-19 aged >18 years who were admitted to the ICU between March 2020 and July 2022. The outcomes were mortality, duration of mechanical ventilation, and length of stay. RDW >14.5% was assessed in blood samples within 24 hours of admission.
Results: The mortality rate was 30.5%. Multivariable Cox regression analysis showed an association between increased RDW and 30-day mortality (hazard ratio
, 3.64; 95% CI, 1.54-8.65), 90-day mortality (HR, 3.66; 95% CI, 1.59-8.40), and shorter duration of invasive ventilation (2.7 ventilator-free days, P=0.033).
Conclusions: Increased RDW in COVID-19 patients at ICU admission was associated with increased 30-day and 90-day mortalities, and shorter duration of invasive ventilation. Thus, RDW can be used as a surrogate biomarker for clinical outcomes in COVID-19 patients admitted to the ICU.
Keywords: COVID-19; biomarkers; length of stay; mortality; red cell distribution width.