tetano
Editor, Senior Moderator
Acta Pharmacol Sin
. 2021 Mar 19.
doi: 10.1038/s41401-021-00627-2. Online ahead of print.
Clinical characteristics and related risk factors of disease severity in 101 COVID-19 patients hospitalized in Wuhan, China
Xue-Qing Liu[SUP] #[/SUP][SUP] 1 2 [/SUP], Shan Xue[SUP] #[/SUP][SUP] 1 2 [/SUP], Jia-Bo Xu[SUP] #[/SUP][SUP] 1 2 [/SUP], Heng Ge[SUP] 3 4 [/SUP], Qing Mao[SUP] 5 6 [/SUP], Xin-Hui Xu[SUP] 7 8 [/SUP], Han-Dong Jiang[SUP] 9 10 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) broke out in December 2019. Due its high morbility and mortality, it is necessary to summarize the clinical characteristics of COVID-19 patients to provide more theoretical basis for future treatment. In the current study, we conducted a retrospective analysis of the clinical characteristics of COVID-19 patients and explored the risk factors for the severity of illness. A total of 101 COVID-19 patients hospitalized in Leishenshan Hospital (Wuhan, China) was classified into three sub-types: moderate (n = 47), severe (n = 36), and critical (n = 18); their clinical data were collected from the Electronic Medical Record. We showed that among the 101 COVID-19 patients, the median age was 62 years (IQR 51-74); 50 (49.5%) patients were accompanied by hypertension, while 25 (24.8%) and 22 (21.8%) patients suffered from diabetes and heart diseases, respectively, with complications. All patients were from Wuhan who had a definite history of exposure to the epidemic area. Multivariate logistic regression analysis revealed that older age, diabetes, chronic liver disease, percentage of neutrophils (N%) > 75%, CRP > 4 mg/L, D-dimer > 0.55 mg/L, IL-2R > 710 U/mL, IL-8 > 62 pg/mL, and IL-10 > 9.1 pg/mL were independent variables associated with severe COVID-19. In conclusion, we have identified the independent risk factors for the severity of COVID-19 pneumonia, including older age, diabetes, chronic liver disease, higher levels of N%, CRP, D-dimer, IL-2R, IL-8, and IL-10, providing evidence for more accurate risk prediction.
Keywords: clinical features; coronavirus disease 2019 (COVID-19); disease severity; retrospective analysis; risk factors; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
. 2021 Mar 19.
doi: 10.1038/s41401-021-00627-2. Online ahead of print.
Clinical characteristics and related risk factors of disease severity in 101 COVID-19 patients hospitalized in Wuhan, China
Xue-Qing Liu[SUP] #[/SUP][SUP] 1 2 [/SUP], Shan Xue[SUP] #[/SUP][SUP] 1 2 [/SUP], Jia-Bo Xu[SUP] #[/SUP][SUP] 1 2 [/SUP], Heng Ge[SUP] 3 4 [/SUP], Qing Mao[SUP] 5 6 [/SUP], Xin-Hui Xu[SUP] 7 8 [/SUP], Han-Dong Jiang[SUP] 9 10 [/SUP]
Affiliations
- PMID: 33742107
- DOI: 10.1038/s41401-021-00627-2
Abstract
Coronavirus disease 2019 (COVID-19) broke out in December 2019. Due its high morbility and mortality, it is necessary to summarize the clinical characteristics of COVID-19 patients to provide more theoretical basis for future treatment. In the current study, we conducted a retrospective analysis of the clinical characteristics of COVID-19 patients and explored the risk factors for the severity of illness. A total of 101 COVID-19 patients hospitalized in Leishenshan Hospital (Wuhan, China) was classified into three sub-types: moderate (n = 47), severe (n = 36), and critical (n = 18); their clinical data were collected from the Electronic Medical Record. We showed that among the 101 COVID-19 patients, the median age was 62 years (IQR 51-74); 50 (49.5%) patients were accompanied by hypertension, while 25 (24.8%) and 22 (21.8%) patients suffered from diabetes and heart diseases, respectively, with complications. All patients were from Wuhan who had a definite history of exposure to the epidemic area. Multivariate logistic regression analysis revealed that older age, diabetes, chronic liver disease, percentage of neutrophils (N%) > 75%, CRP > 4 mg/L, D-dimer > 0.55 mg/L, IL-2R > 710 U/mL, IL-8 > 62 pg/mL, and IL-10 > 9.1 pg/mL were independent variables associated with severe COVID-19. In conclusion, we have identified the independent risk factors for the severity of COVID-19 pneumonia, including older age, diabetes, chronic liver disease, higher levels of N%, CRP, D-dimer, IL-2R, IL-8, and IL-10, providing evidence for more accurate risk prediction.
Keywords: clinical features; coronavirus disease 2019 (COVID-19); disease severity; retrospective analysis; risk factors; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).