tetano
Editor, Senior Moderator
Acta Paediatr
. 2020 Jun 17.
doi: 10.1111/apa.15422. Online ahead of print.
Novel Coronavirus Infection (COVID-19) in Children Younger Than One Year: A Systematic Review of Symptoms, Management and Outcomes
Ali Ahmed Raba[SUP] 1 2 [/SUP], Anis Abobaker[SUP] 3 [/SUP], Ismail Suliman Elgenaidi[SUP] 4 [/SUP], Ahmed Daoud[SUP] 5 [/SUP]
Affiliations
Abstract
Aim: This aim of this systematic review and meta-analysis was to evaluate the clinical characteristics of COVID-19 in neonates and children under one year of age.
Methods: A systematic literature review of the MEDLINE, PubMed, CINAHL, Embase and EBSCO databases was carried out for studies from 1 January to 7 April 2020. We included all papers that addressed clinical manifestations, laboratory results, imaging findings and outcomes in infants and neonates.
Results: Our search identified 77 peer-reviewed papers and 18 papers covering 160 infants were reviewed. One paper was from Vietnam and the other 17 were from China: eight were cross-sectional studies, eight were case reports, one was a case series and one was a prospective cohort study. The most common clinical symptoms were fever (54%) and cough (33%). Most infants were treated symptomatically, with frequent use of various empirical medications. Infants and neonates tended to have more severe COVID-19 disease than older children: 11 (7%) were admitted to intensive care and one infant died. The mortality rate was 0.006%, with favourable outcomes in most cases.
Conclusion: Infants and neonates were more vulnerable to more severe COVID-19 disease than older children, but morbidity and mortality were low.
Keywords: Clinical characteristics; Infants; Neonates; Novel coronavirus; Outcomes.
. 2020 Jun 17.
doi: 10.1111/apa.15422. Online ahead of print.
Novel Coronavirus Infection (COVID-19) in Children Younger Than One Year: A Systematic Review of Symptoms, Management and Outcomes
Ali Ahmed Raba[SUP] 1 2 [/SUP], Anis Abobaker[SUP] 3 [/SUP], Ismail Suliman Elgenaidi[SUP] 4 [/SUP], Ahmed Daoud[SUP] 5 [/SUP]
Affiliations
- PMID: 32557789
- DOI: 10.1111/apa.15422
Abstract
Aim: This aim of this systematic review and meta-analysis was to evaluate the clinical characteristics of COVID-19 in neonates and children under one year of age.
Methods: A systematic literature review of the MEDLINE, PubMed, CINAHL, Embase and EBSCO databases was carried out for studies from 1 January to 7 April 2020. We included all papers that addressed clinical manifestations, laboratory results, imaging findings and outcomes in infants and neonates.
Results: Our search identified 77 peer-reviewed papers and 18 papers covering 160 infants were reviewed. One paper was from Vietnam and the other 17 were from China: eight were cross-sectional studies, eight were case reports, one was a case series and one was a prospective cohort study. The most common clinical symptoms were fever (54%) and cough (33%). Most infants were treated symptomatically, with frequent use of various empirical medications. Infants and neonates tended to have more severe COVID-19 disease than older children: 11 (7%) were admitted to intensive care and one infant died. The mortality rate was 0.006%, with favourable outcomes in most cases.
Conclusion: Infants and neonates were more vulnerable to more severe COVID-19 disease than older children, but morbidity and mortality were low.
Keywords: Clinical characteristics; Infants; Neonates; Novel coronavirus; Outcomes.