tetano
Editor, Senior Moderator
Acta Paediatr
. 2021 Nov 4.
doi: 10.1111/apa.16173. Online ahead of print.
New-onset celiac disease in children during COVID-19 pandemic
M Cakir[SUP] 1 [/SUP], B Guven[SUP] 1 [/SUP], F Issi[SUP] 1 [/SUP], Esra Ozkaya[SUP] 2 [/SUP]
Affiliations
Abstract
Aim: We aimed to analyze the influence of COVID-19 pandemic on the frequency and clinical presentation of celiac disease.
Methods: The study included the patients with celiac disease since January 2008. They were divided into 2 groups; [diagnosed in pre-pandemic (January 2008 and February 2020) (n=148) and, in pandemic period (March 2020 and June 2021) (n=47)]. Clinical and histological findings were compared between groups. Additionally, data about severe acute respiratory syndrome coronavirus 2 infection were obtained in subgroup patients (n=22) with celiac disease diagnosed during pandemic period.
Results: Number of the patients per year (12.1 to 37.6) and percentage of patients that were diagnosed celiac disease/total endoscopy was increased during the pandemic period (2.2% vs. 10%, p<0.00001). The association of celiac disease with type 1 diabetes mellitus was significantly high in pandemic period (4% vs. 17%, p=0.002). Frequency of moderate-severe mucosal lesions was low in pandemic period (42.4% vs. 81.7%, p=0.0001). Clinical and laboratory markers for the past severe acute respiratory syndrome coronavirus 2 infection were found in 36.3% of patients diagnosed during the pandemic period.
Conclusion: It seems that the frequency of celiac disease and its association with type 1 diabetes mellitus is increased during COVID-19 pandemic in children.
Keywords: SARS-CoV-2; celiac disease; type 1 diabetes mellitus.
. 2021 Nov 4.
doi: 10.1111/apa.16173. Online ahead of print.
New-onset celiac disease in children during COVID-19 pandemic
M Cakir[SUP] 1 [/SUP], B Guven[SUP] 1 [/SUP], F Issi[SUP] 1 [/SUP], Esra Ozkaya[SUP] 2 [/SUP]
Affiliations
- PMID: 34738264
- DOI: 10.1111/apa.16173
Abstract
Aim: We aimed to analyze the influence of COVID-19 pandemic on the frequency and clinical presentation of celiac disease.
Methods: The study included the patients with celiac disease since January 2008. They were divided into 2 groups; [diagnosed in pre-pandemic (January 2008 and February 2020) (n=148) and, in pandemic period (March 2020 and June 2021) (n=47)]. Clinical and histological findings were compared between groups. Additionally, data about severe acute respiratory syndrome coronavirus 2 infection were obtained in subgroup patients (n=22) with celiac disease diagnosed during pandemic period.
Results: Number of the patients per year (12.1 to 37.6) and percentage of patients that were diagnosed celiac disease/total endoscopy was increased during the pandemic period (2.2% vs. 10%, p<0.00001). The association of celiac disease with type 1 diabetes mellitus was significantly high in pandemic period (4% vs. 17%, p=0.002). Frequency of moderate-severe mucosal lesions was low in pandemic period (42.4% vs. 81.7%, p=0.0001). Clinical and laboratory markers for the past severe acute respiratory syndrome coronavirus 2 infection were found in 36.3% of patients diagnosed during the pandemic period.
Conclusion: It seems that the frequency of celiac disease and its association with type 1 diabetes mellitus is increased during COVID-19 pandemic in children.
Keywords: SARS-CoV-2; celiac disease; type 1 diabetes mellitus.