tetano
Editor, Senior Moderator
Acta Neuropathol
. 2024 Jul 25;148(1):11.
doi: 10.1007/s00401-024-02770-6. High throughput spatial immune mapping reveals an innate immune scar in post-COVID-19 brains
Marius Schwabenland[SUP] 1 [/SUP], Dilara Hasavci[SUP] 1 [/SUP], Sibylle Frase[SUP] 2 [/SUP], Katharina Wolf[SUP] 2 3 [/SUP], Nikolaus Deigendesch[SUP] 4 [/SUP], Joerg M Buescher[SUP] 5 [/SUP], Kirsten D Mertz[SUP] 6 7 [/SUP], Benjamin Ondruschka[SUP] 8 [/SUP], Hermann Altmeppen[SUP] 9 [/SUP], Jakob Matschke[SUP] 9 [/SUP], Markus Glatzel[SUP] 9 [/SUP], Stephan Frank[SUP] 10 [/SUP], Robert Thimme[SUP] 11 [/SUP], Juergen Beck[SUP] 3 [/SUP], Jonas A Hosp[SUP] 2 [/SUP], Thomas Blank[SUP] 1 [/SUP], Bertram Bengsch[SUP] 11 12 [/SUP], Marco Prinz[SUP] 13 14 [/SUP]
Affiliations
The underlying pathogenesis of neurological sequelae in post-COVID-19 patients remains unclear. Here, we used multidimensional spatial immune phenotyping and machine learning methods on brains from initial COVID-19 survivors to identify the biological correlate associated with previous SARS-CoV-2 challenge. Compared to healthy controls, individuals with post-COVID-19 revealed a high percentage of TMEM119[SUP]+[/SUP]P2RY12[SUP]+[/SUP]CD68[SUP]+[/SUP]Iba1[SUP]+[/SUP]HLA-DR[SUP]+[/SUP]CD11c[SUP]+[/SUP]SCAMP2[SUP]+[/SUP] microglia assembled in prototypical cellular nodules. In contrast to acute SARS-CoV-2 cases, the frequency of CD8[SUP]+[/SUP] parenchymal T cells was reduced, suggesting an immune shift toward innate immune activation that may contribute to neurological alterations in post-COVID-19 patients.
Keywords: COVID-19; Imaging mass cytometry; Long-COVID; Microglia; Neuro-long-COVID-19; PACS; PCC; Post-COVID condition; Post-acute COVID syndrome; SARS-CoV-2.
. 2024 Jul 25;148(1):11.
doi: 10.1007/s00401-024-02770-6. High throughput spatial immune mapping reveals an innate immune scar in post-COVID-19 brains
Marius Schwabenland[SUP] 1 [/SUP], Dilara Hasavci[SUP] 1 [/SUP], Sibylle Frase[SUP] 2 [/SUP], Katharina Wolf[SUP] 2 3 [/SUP], Nikolaus Deigendesch[SUP] 4 [/SUP], Joerg M Buescher[SUP] 5 [/SUP], Kirsten D Mertz[SUP] 6 7 [/SUP], Benjamin Ondruschka[SUP] 8 [/SUP], Hermann Altmeppen[SUP] 9 [/SUP], Jakob Matschke[SUP] 9 [/SUP], Markus Glatzel[SUP] 9 [/SUP], Stephan Frank[SUP] 10 [/SUP], Robert Thimme[SUP] 11 [/SUP], Juergen Beck[SUP] 3 [/SUP], Jonas A Hosp[SUP] 2 [/SUP], Thomas Blank[SUP] 1 [/SUP], Bertram Bengsch[SUP] 11 12 [/SUP], Marco Prinz[SUP] 13 14 [/SUP]
Affiliations
- PMID: 39060438
- PMCID: PMC11281987
- DOI: 10.1007/s00401-024-02770-6
The underlying pathogenesis of neurological sequelae in post-COVID-19 patients remains unclear. Here, we used multidimensional spatial immune phenotyping and machine learning methods on brains from initial COVID-19 survivors to identify the biological correlate associated with previous SARS-CoV-2 challenge. Compared to healthy controls, individuals with post-COVID-19 revealed a high percentage of TMEM119[SUP]+[/SUP]P2RY12[SUP]+[/SUP]CD68[SUP]+[/SUP]Iba1[SUP]+[/SUP]HLA-DR[SUP]+[/SUP]CD11c[SUP]+[/SUP]SCAMP2[SUP]+[/SUP] microglia assembled in prototypical cellular nodules. In contrast to acute SARS-CoV-2 cases, the frequency of CD8[SUP]+[/SUP] parenchymal T cells was reduced, suggesting an immune shift toward innate immune activation that may contribute to neurological alterations in post-COVID-19 patients.
Keywords: COVID-19; Imaging mass cytometry; Long-COVID; Microglia; Neuro-long-COVID-19; PACS; PCC; Post-COVID condition; Post-acute COVID syndrome; SARS-CoV-2.