tetano
Editor, Senior Moderator
Acta Biomed
. 2022 Jun 29;93(S1):e20222140.
doi: 10.23750/abm.v93iS1.12885.
Neurological disorders in COVID-19: a case of Acute Disseminated Encephalomyelitis in an adult patient
Lorenzo Verriello[SUP] 1 [/SUP], Sara Pez[SUP] 2 [/SUP], Giada Pauletto[SUP] 3 [/SUP], Serena D'Agostini[SUP] 4 [/SUP], Annacarmen Nilo[SUP] 5 [/SUP], Gian Luigi Gigli[SUP] 6 [/SUP], Mariarosaria Valente[SUP] 7 [/SUP]
Affiliations
Abstract
Different neurological complications associated with the severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection have been widely documented. Acute disseminated encephalomyelitis (ADEM) is a rare immune-mediated demyelinating disorder, described within the spectrum of neurological manifestations of COVID-19. Herein, we describe a case of adult-ADEM presenting with diplopia and slowly progressive ataxia developed one month after SARS-CoV-2 infection. Brain magnetic resonance imaging (MRI) revealed acute multifocal demyelinating lesions throughout the brain. Other possible etiologies have been ruled out. After treatment with high-dose steroids, we observed a progressive clinical and radiological improvement. A 4-months follow-up showed complete clinical recovery. Although extremely rare, ADEM could be associated to SARS-CoV-2 infection and should be considered in the differential diagnosis. Early recognition of this COVID-19 neurological complication, even in the absence of pulmonary involvement, is important to start a prompt immune-modulatory treatment and, consequently, ensure a good outcome
. 2022 Jun 29;93(S1):e20222140.
doi: 10.23750/abm.v93iS1.12885.
Neurological disorders in COVID-19: a case of Acute Disseminated Encephalomyelitis in an adult patient
Lorenzo Verriello[SUP] 1 [/SUP], Sara Pez[SUP] 2 [/SUP], Giada Pauletto[SUP] 3 [/SUP], Serena D'Agostini[SUP] 4 [/SUP], Annacarmen Nilo[SUP] 5 [/SUP], Gian Luigi Gigli[SUP] 6 [/SUP], Mariarosaria Valente[SUP] 7 [/SUP]
Affiliations
- PMID: 35765956
- DOI: 10.23750/abm.v93iS1.12885
Abstract
Different neurological complications associated with the severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection have been widely documented. Acute disseminated encephalomyelitis (ADEM) is a rare immune-mediated demyelinating disorder, described within the spectrum of neurological manifestations of COVID-19. Herein, we describe a case of adult-ADEM presenting with diplopia and slowly progressive ataxia developed one month after SARS-CoV-2 infection. Brain magnetic resonance imaging (MRI) revealed acute multifocal demyelinating lesions throughout the brain. Other possible etiologies have been ruled out. After treatment with high-dose steroids, we observed a progressive clinical and radiological improvement. A 4-months follow-up showed complete clinical recovery. Although extremely rare, ADEM could be associated to SARS-CoV-2 infection and should be considered in the differential diagnosis. Early recognition of this COVID-19 neurological complication, even in the absence of pulmonary involvement, is important to start a prompt immune-modulatory treatment and, consequently, ensure a good outcome