tetano
Editor, Senior Moderator
Acta Biomed
. 2022 Jan 19;92(6):e2021543.
doi: 10.23750/abm.v92i6.11991.
Multisystem inflammatory syndrome in children (MIS-C) related to COVID-19 infection in the state of Qatar: Association with Kawasaki-like Illness
Samar Magboul[SUP] 1 [/SUP], Ahmed Khalil[SUP] 2 [/SUP], Manasik Hassan[SUP] 3 [/SUP], Basel Habra[SUP] 4 [/SUP], Ahmad Alshami[SUP] 5 [/SUP], Shabina Khan[SUP] 6 [/SUP], Khaled Ellithy[SUP] 7 [/SUP], Hossamaldein Ali[SUP] 8 [/SUP], Abdulla AlHothi[SUP] 9 [/SUP], Eman AlMaslamani[SUP] 10 [/SUP], Mohamed AlAmri[SUP] 11 [/SUP], Vincenzo De Sanctis[SUP] 12 [/SUP], Ashraf T Soliman[SUP] 13 [/SUP]
Affiliations
Abstract
Introduction: World Health Organization (WHO) is encouraging reporting of children with Multisystem Inflammatory Syndrome (MIS-C) associated with SARS-CoV-2 infection for better understanding and management of the disease.
Methodology: This retrospective study included the first 15 pediatrics patient with a confirmed diagnosis of MIS-C associated with SARS-CoV-2 infection in the state of Qatar. We studied and analyzed their demographic data, clinical manifestations, laboratory tests, treatment, and outcome.
Results: A total of 15 children were studied (mean age 3.5 ± 2.7year). Recent severe acute respiratory syndrome coronavirus 2 infection was identified in all of them (100%). The majority of these patients had 4 or more systems involvement. Nine of the 15 presented with Kawasaki disease - picture and all had gastrointestinal symptoms (vomiting and diarrhea). Five required Pediatrics Intensive Care Unit (PICU) admission. Lab investigations revealed high D-Dimer, hyponatremia, and hypoalbuminemia in all. Low hemoglobin (Hb) , thrombocytopenia, and sterile pyuria occurred in 86.6%, 60% and 75% of them, respectively. Treatment with combined anti-inflammatory medications (intravenous immunoglobulin, corticosteroids) was used in along with immunomodulatory agents (Anakinra) in a selected group of refractory patients. No mortality happened.
Conclusion: Our young children who presented with MIS-C related to SARS-CoV-2 infection had significantly higher Kawasaki-disease picture compared to other reports. One third of them required PICU admission but no mortality occurred.
. 2022 Jan 19;92(6):e2021543.
doi: 10.23750/abm.v92i6.11991.
Multisystem inflammatory syndrome in children (MIS-C) related to COVID-19 infection in the state of Qatar: Association with Kawasaki-like Illness
Samar Magboul[SUP] 1 [/SUP], Ahmed Khalil[SUP] 2 [/SUP], Manasik Hassan[SUP] 3 [/SUP], Basel Habra[SUP] 4 [/SUP], Ahmad Alshami[SUP] 5 [/SUP], Shabina Khan[SUP] 6 [/SUP], Khaled Ellithy[SUP] 7 [/SUP], Hossamaldein Ali[SUP] 8 [/SUP], Abdulla AlHothi[SUP] 9 [/SUP], Eman AlMaslamani[SUP] 10 [/SUP], Mohamed AlAmri[SUP] 11 [/SUP], Vincenzo De Sanctis[SUP] 12 [/SUP], Ashraf T Soliman[SUP] 13 [/SUP]
Affiliations
- PMID: 35075072
- DOI: 10.23750/abm.v92i6.11991
Abstract
Introduction: World Health Organization (WHO) is encouraging reporting of children with Multisystem Inflammatory Syndrome (MIS-C) associated with SARS-CoV-2 infection for better understanding and management of the disease.
Methodology: This retrospective study included the first 15 pediatrics patient with a confirmed diagnosis of MIS-C associated with SARS-CoV-2 infection in the state of Qatar. We studied and analyzed their demographic data, clinical manifestations, laboratory tests, treatment, and outcome.
Results: A total of 15 children were studied (mean age 3.5 ± 2.7year). Recent severe acute respiratory syndrome coronavirus 2 infection was identified in all of them (100%). The majority of these patients had 4 or more systems involvement. Nine of the 15 presented with Kawasaki disease - picture and all had gastrointestinal symptoms (vomiting and diarrhea). Five required Pediatrics Intensive Care Unit (PICU) admission. Lab investigations revealed high D-Dimer, hyponatremia, and hypoalbuminemia in all. Low hemoglobin (Hb) , thrombocytopenia, and sterile pyuria occurred in 86.6%, 60% and 75% of them, respectively. Treatment with combined anti-inflammatory medications (intravenous immunoglobulin, corticosteroids) was used in along with immunomodulatory agents (Anakinra) in a selected group of refractory patients. No mortality happened.
Conclusion: Our young children who presented with MIS-C related to SARS-CoV-2 infection had significantly higher Kawasaki-disease picture compared to other reports. One third of them required PICU admission but no mortality occurred.