tetano
Editor, Senior Moderator
Acta Anaesthesiol Scand
. 2020 Dec 9.
doi: 10.1111/aas.13757. Online ahead of print.
Effects of Inhaled Nitric Oxide in COVID-19 induced ARDS - is it worthwhile?
Christopher Lotz[SUP] 1 [/SUP], Ralf M Muellenbach[SUP] 2 [/SUP], Patrick Meybohm[SUP] 1 [/SUP], Haitham Mutlak[SUP] 3 [/SUP], Philipp M Lepper[SUP] 4 [/SUP], Caroline-Barbara Rolfes[SUP] 2 [/SUP], Asghar Peivandi[SUP] 5 [/SUP], Jan Stumpner[SUP] 1 [/SUP], Markus Kredel[SUP] 1 [/SUP], Peter Kranke[SUP] 1 [/SUP], Iuliu Torje[SUP] 2 [/SUP], Christian Reyher[SUP] 2 [/SUP]
Affiliations
Abstract
Background: Changes in pulmonary hemodynamics and ventilation/perfusion were proposed as hallmarks of Coronavirus disease 2019 (COVID-19) induced acute respiratory distress syndrome (ARDS). Inhaled nitric oxide (iNO) may overcome these issues and improve arterial oxygenation.
Methods: We retrospectively analyzed arterial oxygenation and pulmonary vasoreactivity in seven COVID-19 ARDS patients receiving 20ppm iNO for 15-30 minutes.
Results: The inhalation of NO significantly improved oxygenation. All patients with severe ARDS had higher partial pressures of oxygen and reduced pulmonary vascular resistance. Significant changes in pulmonary shunting were not observed.
Conclusion: Overall, iNO could provide immediate help and delay respiratory deterioration in COVID-19 induced moderate to severe ARDS.
Keywords: ARDS; COVID-19; Nitric Oxide; Vasoreactivity.
. 2020 Dec 9.
doi: 10.1111/aas.13757. Online ahead of print.
Effects of Inhaled Nitric Oxide in COVID-19 induced ARDS - is it worthwhile?
Christopher Lotz[SUP] 1 [/SUP], Ralf M Muellenbach[SUP] 2 [/SUP], Patrick Meybohm[SUP] 1 [/SUP], Haitham Mutlak[SUP] 3 [/SUP], Philipp M Lepper[SUP] 4 [/SUP], Caroline-Barbara Rolfes[SUP] 2 [/SUP], Asghar Peivandi[SUP] 5 [/SUP], Jan Stumpner[SUP] 1 [/SUP], Markus Kredel[SUP] 1 [/SUP], Peter Kranke[SUP] 1 [/SUP], Iuliu Torje[SUP] 2 [/SUP], Christian Reyher[SUP] 2 [/SUP]
Affiliations
- PMID: 33296498
- DOI: 10.1111/aas.13757
Abstract
Background: Changes in pulmonary hemodynamics and ventilation/perfusion were proposed as hallmarks of Coronavirus disease 2019 (COVID-19) induced acute respiratory distress syndrome (ARDS). Inhaled nitric oxide (iNO) may overcome these issues and improve arterial oxygenation.
Methods: We retrospectively analyzed arterial oxygenation and pulmonary vasoreactivity in seven COVID-19 ARDS patients receiving 20ppm iNO for 15-30 minutes.
Results: The inhalation of NO significantly improved oxygenation. All patients with severe ARDS had higher partial pressures of oxygen and reduced pulmonary vascular resistance. Significant changes in pulmonary shunting were not observed.
Conclusion: Overall, iNO could provide immediate help and delay respiratory deterioration in COVID-19 induced moderate to severe ARDS.
Keywords: ARDS; COVID-19; Nitric Oxide; Vasoreactivity.