tetano
Editor, Senior Moderator
ACS Nano
. 2021 Apr 7.
doi: 10.1021/acsnano.1c00629. Online ahead of print.
Carbon-Based Nanomaterials: Promising Antiviral Agents to Combat COVID-19 in the Microbial-Resistant Era
?ngel Serrano-Aroca[SUP] 1 [/SUP], Kazuo Takayama[SUP] 2 [/SUP], Alberto Tu??n-Molina[SUP] 1 [/SUP], Murat Seyran[SUP] 3 [/SUP], Sk Sarif Hassan[SUP] 4 [/SUP], Pabitra Pal Choudhury[SUP] 5 [/SUP], Vladimir N Uversky[SUP] 6 [/SUP], Kenneth Lundstrom[SUP] 7 [/SUP], Parise Adadi[SUP] 8 [/SUP], Giorgio Pal?[SUP] 9 [/SUP], Alaa A A Aljabali[SUP] 10 [/SUP], Gaurav Chauhan[SUP] 11 [/SUP], Ramesh Kandimalla[SUP] 12 13 [/SUP], Murtaza M Tambuwala[SUP] 14 [/SUP], Amos Lal[SUP] 15 [/SUP], Tarek Mohamed Abd El-Aziz[SUP] 16 17 [/SUP], Samendra Sherchan[SUP] 18 [/SUP], Debmalya Barh[SUP] 19 [/SUP], Elrashdy M Redwan[SUP] 20 21 [/SUP], Nicolas G Bazan[SUP] 22 [/SUP], Yogendra Kumar Mishra[SUP] 23 [/SUP], Bruce D Uhal[SUP] 24 [/SUP], Adam Brufsky[SUP] 25 [/SUP]
Affiliations
Abstract
Therapeutic options for the highly pathogenic human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing the current pandemic coronavirus disease (COVID-19) are urgently needed. COVID-19 is associated with viral pneumonia and acute respiratory distress syndrome causing significant morbidity and mortality. The proposed treatments for COVID-19 have shown little or no effect in the clinic so far. Additionally, bacterial and fungal pathogens contribute to the SARS-CoV-2-mediated pneumonia disease complex. The antibiotic resistance in pneumonia treatment is increasing at an alarming rate. Therefore, carbon-based nanomaterials (CBNs), such as fullerene, carbon dots, graphene, and their derivatives constitute a promising alternative due to their wide-spectrum antimicrobial activity, biocompatibility, biodegradability, and capacity to induce tissue regeneration. Furthermore, the antimicrobial mode of action is mainly physical (e.g., membrane distortion), characterized by a low risk of antimicrobial resistance. In this Review, we evaluated the literature on the antiviral activity and broad-spectrum antimicrobial properties of CBNs. CBNs had antiviral activity against 13 enveloped positive-sense single-stranded RNA viruses, including SARS-CoV-2. CBNs with low or no toxicity to humans are promising therapeutics against the COVID-19 pneumonia complex with other viruses, bacteria, and fungi, including those that are multidrug-resistant.
Keywords: COVID-19; SARS-CoV-2; antiviral properties; carbon dots; carbon-based nanomaterials; fullerene; graphene; pneumonia; tissue regeneration.
. 2021 Apr 7.
doi: 10.1021/acsnano.1c00629. Online ahead of print.
Carbon-Based Nanomaterials: Promising Antiviral Agents to Combat COVID-19 in the Microbial-Resistant Era
?ngel Serrano-Aroca[SUP] 1 [/SUP], Kazuo Takayama[SUP] 2 [/SUP], Alberto Tu??n-Molina[SUP] 1 [/SUP], Murat Seyran[SUP] 3 [/SUP], Sk Sarif Hassan[SUP] 4 [/SUP], Pabitra Pal Choudhury[SUP] 5 [/SUP], Vladimir N Uversky[SUP] 6 [/SUP], Kenneth Lundstrom[SUP] 7 [/SUP], Parise Adadi[SUP] 8 [/SUP], Giorgio Pal?[SUP] 9 [/SUP], Alaa A A Aljabali[SUP] 10 [/SUP], Gaurav Chauhan[SUP] 11 [/SUP], Ramesh Kandimalla[SUP] 12 13 [/SUP], Murtaza M Tambuwala[SUP] 14 [/SUP], Amos Lal[SUP] 15 [/SUP], Tarek Mohamed Abd El-Aziz[SUP] 16 17 [/SUP], Samendra Sherchan[SUP] 18 [/SUP], Debmalya Barh[SUP] 19 [/SUP], Elrashdy M Redwan[SUP] 20 21 [/SUP], Nicolas G Bazan[SUP] 22 [/SUP], Yogendra Kumar Mishra[SUP] 23 [/SUP], Bruce D Uhal[SUP] 24 [/SUP], Adam Brufsky[SUP] 25 [/SUP]
Affiliations
- PMID: 33826850
- DOI: 10.1021/acsnano.1c00629
Abstract
Therapeutic options for the highly pathogenic human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing the current pandemic coronavirus disease (COVID-19) are urgently needed. COVID-19 is associated with viral pneumonia and acute respiratory distress syndrome causing significant morbidity and mortality. The proposed treatments for COVID-19 have shown little or no effect in the clinic so far. Additionally, bacterial and fungal pathogens contribute to the SARS-CoV-2-mediated pneumonia disease complex. The antibiotic resistance in pneumonia treatment is increasing at an alarming rate. Therefore, carbon-based nanomaterials (CBNs), such as fullerene, carbon dots, graphene, and their derivatives constitute a promising alternative due to their wide-spectrum antimicrobial activity, biocompatibility, biodegradability, and capacity to induce tissue regeneration. Furthermore, the antimicrobial mode of action is mainly physical (e.g., membrane distortion), characterized by a low risk of antimicrobial resistance. In this Review, we evaluated the literature on the antiviral activity and broad-spectrum antimicrobial properties of CBNs. CBNs had antiviral activity against 13 enveloped positive-sense single-stranded RNA viruses, including SARS-CoV-2. CBNs with low or no toxicity to humans are promising therapeutics against the COVID-19 pneumonia complex with other viruses, bacteria, and fungi, including those that are multidrug-resistant.
Keywords: COVID-19; SARS-CoV-2; antiviral properties; carbon dots; carbon-based nanomaterials; fullerene; graphene; pneumonia; tissue regeneration.