tetano
Editor, Senior Moderator
ACS Nano
. 2024 Sep 24.
doi: 10.1021/acsnano.4c04631. Online ahead of print. An Inhalable Nanoshield for Effective Prevention of Influenza Virus Infections
Jing Li[SUP] 1 [/SUP], Xue-Hui Shi[SUP] 2 [/SUP], Dan-Dan Fu[SUP] 1 [/SUP], Lei Du[SUP] 1 [/SUP], Bo Tang[SUP] 1 [/SUP], Jian Ao[SUP] 1 [/SUP], Ai-Xin Ma[SUP] 2 [/SUP], Yi-Ning Hou[SUP] 1 [/SUP], Zhi-Gang Wang[SUP] 2 [/SUP], Shu-Lin Liu[SUP] 2 [/SUP], Dai-Wen Pang[SUP] 1 2 [/SUP]
Affiliations
Influenza virus (IV) infection currently poses a serious and continuing threat to the global public health. Developing effective prevention strategies is important to defend against infection and spread of IV. Here, we developed a triple-protective nanoshield against IV infection in the lungs, formed by self-assembling DSPE-PEG amphiphilic polymers encapsulating the flu-preventive antiviral drug Arbidol internally. The preventive effect of the nanoshield against virus infection includes increasing the viscosity in the surrounding environment to physically defend against viral entry, forming a hydrated layer to block the interaction between viruses and cells, and inhibiting virus replication. Our finding suggested that a single inhalation of the nanoshield provides effective protection against IV infection for at least 8 h. Thus, this nanoshield may be a potential pandemic protection agent against IV, especially in viral environments, where no prophylactic or therapeutic measures are available.
Keywords: amphiphilic polymers; antiviral defense; influenza virus; nanoshield; virus infection.
. 2024 Sep 24.
doi: 10.1021/acsnano.4c04631. Online ahead of print. An Inhalable Nanoshield for Effective Prevention of Influenza Virus Infections
Jing Li[SUP] 1 [/SUP], Xue-Hui Shi[SUP] 2 [/SUP], Dan-Dan Fu[SUP] 1 [/SUP], Lei Du[SUP] 1 [/SUP], Bo Tang[SUP] 1 [/SUP], Jian Ao[SUP] 1 [/SUP], Ai-Xin Ma[SUP] 2 [/SUP], Yi-Ning Hou[SUP] 1 [/SUP], Zhi-Gang Wang[SUP] 2 [/SUP], Shu-Lin Liu[SUP] 2 [/SUP], Dai-Wen Pang[SUP] 1 2 [/SUP]
Affiliations
- PMID: 39315858
- DOI: 10.1021/acsnano.4c04631
Influenza virus (IV) infection currently poses a serious and continuing threat to the global public health. Developing effective prevention strategies is important to defend against infection and spread of IV. Here, we developed a triple-protective nanoshield against IV infection in the lungs, formed by self-assembling DSPE-PEG amphiphilic polymers encapsulating the flu-preventive antiviral drug Arbidol internally. The preventive effect of the nanoshield against virus infection includes increasing the viscosity in the surrounding environment to physically defend against viral entry, forming a hydrated layer to block the interaction between viruses and cells, and inhibiting virus replication. Our finding suggested that a single inhalation of the nanoshield provides effective protection against IV infection for at least 8 h. Thus, this nanoshield may be a potential pandemic protection agent against IV, especially in viral environments, where no prophylactic or therapeutic measures are available.
Keywords: amphiphilic polymers; antiviral defense; influenza virus; nanoshield; virus infection.