tetano
Editor, Senior Moderator
ACS ES T Water
. 2023 Sep 8;3(9):2849-2862.
doi: 10.1021/acsestwater.3c00032. Epub 2023 Aug 22. Correlative analysis of wastewater trends with clinical cases and hospitalizations through five dominant variant waves of COVID-19
Qingyu Zhan[SUP] 1 [/SUP], Helena Maria Solo-Gabriele[SUP] 1 [/SUP], Mark E Sharkey[SUP] 2 [/SUP], Ayaaz Amirali[SUP] 1 [/SUP], Cynthia C Beaver[SUP] 3 [/SUP], Melinda M Boone[SUP] 3 [/SUP], Samuel Comerford[SUP] 2 [/SUP], Daniel Cooper[SUP] 4 [/SUP], Elena M Cortizas[SUP] 3 [/SUP], Gabriella A Cosculluela[SUP] 1 [/SUP], Benjamin B Currall[SUP] 3 [/SUP], George S Grills[SUP] 3 [/SUP], Erin Kobetz[SUP] 2 3 [/SUP], Naresh Kumar[SUP] 5 [/SUP], Jennifer Laine[SUP] 6 [/SUP], Walter E Lamar[SUP] 7 [/SUP], Jiangnan Lyu[SUP] 5 [/SUP], Christopher E Mason[SUP] 8 9 10 [/SUP], Brian D Reding[SUP] 6 [/SUP], Matthew A Roca[SUP] 1 [/SUP], Stephan C Schürer[SUP] 3 11 12 [/SUP], Bhavarth S Shukla[SUP] 2 [/SUP], Natasha Schaefer Solle[SUP] 2 3 [/SUP], Maritza M Suarez[SUP] 2 [/SUP], Mario Stevenson[SUP] 1 [/SUP], John J Tallon Jr[SUP] 13 [/SUP], Collette Thomas[SUP] 1 [/SUP], Dušica Vidović[SUP] 11 [/SUP], Sion L Williams[SUP] 3 [/SUP], Xue Yin[SUP] 1 [/SUP], Yalda Zarnegarnia[SUP] 5 [/SUP], Kristina Marie Babler[SUP] 1 [/SUP]
Affiliations
Wastewater-based epidemiology (WBE) has been utilized to track community infections of Coronavirus Disease 2019 (COVID-19) by detecting RNA of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), within samples collected from wastewater. The correlations between community infections and wastewater measurements of the RNA can potentially change as SARS-CoV-2 evolves into new variations by mutating. This study analyzed SARS-CoV-2 RNA, and indicators of human waste in wastewater from two sewersheds of different scales (University of Miami (UM) campus and Miami-Dade County Central District wastewater treatment plant (CDWWTP)) during five internally defined COVID-19 variant dominant periods (Initial, Pre-Delta, Delta, Omicron and Post-Omicron wave). SARS-CoV-2 RNA quantities were compared against COVID-19 clinical cases and hospitalizations to evaluate correlations with wastewater SARS-CoV-2 RNA. Although correlations between documented clinical cases and hospitalizations were high, prevalence for a given wastewater SARS-CoV-2 level varied depending upon the variant analyzed. The correlative relationship was significantly steeper (more cases per level found in wastewater) for the Omicron-dominated period. For hospitalization, the relationships were steepest for the Initial wave, followed by the Delta wave with flatter slopes during all other waves. Overall results were interpreted in the context of SARS-CoV-2 virulence and vaccination rates among the community.
Keywords: Clinical Cases; Hospitalization; SARS-CoV-2; Variants; Wastewater; Wastewater-Based Surveillance.
. 2023 Sep 8;3(9):2849-2862.
doi: 10.1021/acsestwater.3c00032. Epub 2023 Aug 22. Correlative analysis of wastewater trends with clinical cases and hospitalizations through five dominant variant waves of COVID-19
Qingyu Zhan[SUP] 1 [/SUP], Helena Maria Solo-Gabriele[SUP] 1 [/SUP], Mark E Sharkey[SUP] 2 [/SUP], Ayaaz Amirali[SUP] 1 [/SUP], Cynthia C Beaver[SUP] 3 [/SUP], Melinda M Boone[SUP] 3 [/SUP], Samuel Comerford[SUP] 2 [/SUP], Daniel Cooper[SUP] 4 [/SUP], Elena M Cortizas[SUP] 3 [/SUP], Gabriella A Cosculluela[SUP] 1 [/SUP], Benjamin B Currall[SUP] 3 [/SUP], George S Grills[SUP] 3 [/SUP], Erin Kobetz[SUP] 2 3 [/SUP], Naresh Kumar[SUP] 5 [/SUP], Jennifer Laine[SUP] 6 [/SUP], Walter E Lamar[SUP] 7 [/SUP], Jiangnan Lyu[SUP] 5 [/SUP], Christopher E Mason[SUP] 8 9 10 [/SUP], Brian D Reding[SUP] 6 [/SUP], Matthew A Roca[SUP] 1 [/SUP], Stephan C Schürer[SUP] 3 11 12 [/SUP], Bhavarth S Shukla[SUP] 2 [/SUP], Natasha Schaefer Solle[SUP] 2 3 [/SUP], Maritza M Suarez[SUP] 2 [/SUP], Mario Stevenson[SUP] 1 [/SUP], John J Tallon Jr[SUP] 13 [/SUP], Collette Thomas[SUP] 1 [/SUP], Dušica Vidović[SUP] 11 [/SUP], Sion L Williams[SUP] 3 [/SUP], Xue Yin[SUP] 1 [/SUP], Yalda Zarnegarnia[SUP] 5 [/SUP], Kristina Marie Babler[SUP] 1 [/SUP]
Affiliations
- PMID: 38487696
- PMCID: PMC10936583 (available on 2024-09-08)
- DOI: 10.1021/acsestwater.3c00032
Wastewater-based epidemiology (WBE) has been utilized to track community infections of Coronavirus Disease 2019 (COVID-19) by detecting RNA of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), within samples collected from wastewater. The correlations between community infections and wastewater measurements of the RNA can potentially change as SARS-CoV-2 evolves into new variations by mutating. This study analyzed SARS-CoV-2 RNA, and indicators of human waste in wastewater from two sewersheds of different scales (University of Miami (UM) campus and Miami-Dade County Central District wastewater treatment plant (CDWWTP)) during five internally defined COVID-19 variant dominant periods (Initial, Pre-Delta, Delta, Omicron and Post-Omicron wave). SARS-CoV-2 RNA quantities were compared against COVID-19 clinical cases and hospitalizations to evaluate correlations with wastewater SARS-CoV-2 RNA. Although correlations between documented clinical cases and hospitalizations were high, prevalence for a given wastewater SARS-CoV-2 level varied depending upon the variant analyzed. The correlative relationship was significantly steeper (more cases per level found in wastewater) for the Omicron-dominated period. For hospitalization, the relationships were steepest for the Initial wave, followed by the Delta wave with flatter slopes during all other waves. Overall results were interpreted in the context of SARS-CoV-2 virulence and vaccination rates among the community.
Keywords: Clinical Cases; Hospitalization; SARS-CoV-2; Variants; Wastewater; Wastewater-Based Surveillance.