tetano
Editor, Senior Moderator
ACS Chem Neurosci
. 2020 Jun 11.
doi: 10.1021/acschemneuro.0c00249. Online ahead of print.
Proinflammatory Cytokines in the Olfactory Mucosa Result in COVID-19 Induced Anosmia
Abolfazl Torabi[SUP] 1 [/SUP], Esmaeil Mohammadbagheri[SUP] 2 [/SUP], Nader Akbari Dilmaghani[SUP] 3 [/SUP], Amir-Hossein Bayat[SUP] 4 [/SUP], Mobina Fathi[SUP] 1 [/SUP], Kimia Vakili[SUP] 1 [/SUP], Rafieh Alizadeh[SUP] 5 [/SUP], Omidvar Rezaeimirghaed[SUP] 6 [/SUP], Mohammadreza Hajiesmaeili[SUP] 7 [/SUP], Mahtab Ramezani[SUP] 6 [/SUP], Leila Simani[SUP] 6 [/SUP], Abbas Aliaghaei[SUP] 1 [/SUP]
Affiliations
Abstract
Studies have found increased rates of dysosmia in patients with Novel Coronavirus disease 2019 (COVID-19). However, the mechanism that causes olfactory loss is unknown. The primary objective of this study was to explore local proinflammatory cytokine levels in the olfactory epithelium in patients with COVID-19. Biopsies of the olfactory epithelium were taken from patients with confirmed COVID-19 as well as uninfected controls. Levels of tumor necrosis factor α (TNF-α) and interleukin-1-beta (IL-1β) were assessed using ELISA and compared between groups. Average TNF-α levels were significantly increased in the olfactory epithelium of the COVID-19 group compared to the control group (P < 0.05). However, no differences in IL-1β were seen between groups. Elevated levels of the proinflammatory cytokine TNF-α were seen in the olfactory epithelium in patients with COVID-19. This suggests that direct inflammation of the olfactory epithelium could play a role in the acute olfactory loss described in many patients with COVID-19.
Keywords: Anosmia; COVID-19; Inflammation; Tumor necrosis factor-alpha.
. 2020 Jun 11.
doi: 10.1021/acschemneuro.0c00249. Online ahead of print.
Proinflammatory Cytokines in the Olfactory Mucosa Result in COVID-19 Induced Anosmia
Abolfazl Torabi[SUP] 1 [/SUP], Esmaeil Mohammadbagheri[SUP] 2 [/SUP], Nader Akbari Dilmaghani[SUP] 3 [/SUP], Amir-Hossein Bayat[SUP] 4 [/SUP], Mobina Fathi[SUP] 1 [/SUP], Kimia Vakili[SUP] 1 [/SUP], Rafieh Alizadeh[SUP] 5 [/SUP], Omidvar Rezaeimirghaed[SUP] 6 [/SUP], Mohammadreza Hajiesmaeili[SUP] 7 [/SUP], Mahtab Ramezani[SUP] 6 [/SUP], Leila Simani[SUP] 6 [/SUP], Abbas Aliaghaei[SUP] 1 [/SUP]
Affiliations
- PMID: 32525657
- DOI: 10.1021/acschemneuro.0c00249
Abstract
Studies have found increased rates of dysosmia in patients with Novel Coronavirus disease 2019 (COVID-19). However, the mechanism that causes olfactory loss is unknown. The primary objective of this study was to explore local proinflammatory cytokine levels in the olfactory epithelium in patients with COVID-19. Biopsies of the olfactory epithelium were taken from patients with confirmed COVID-19 as well as uninfected controls. Levels of tumor necrosis factor α (TNF-α) and interleukin-1-beta (IL-1β) were assessed using ELISA and compared between groups. Average TNF-α levels were significantly increased in the olfactory epithelium of the COVID-19 group compared to the control group (P < 0.05). However, no differences in IL-1β were seen between groups. Elevated levels of the proinflammatory cytokine TNF-α were seen in the olfactory epithelium in patients with COVID-19. This suggests that direct inflammation of the olfactory epithelium could play a role in the acute olfactory loss described in many patients with COVID-19.
Keywords: Anosmia; COVID-19; Inflammation; Tumor necrosis factor-alpha.