Acquired severe aplastic anemia after H1N1 influenza virus vaccination successfully treated with allogeneic bone marrow transplantation
Irene Donnini & Barbara Scappini & Stefano Guidi &
Giovanni Longo & Alberto Bosi
Received: 9 October 2010 / Accepted: 7 June 2011 / Published online: 17 June 2011
# Springer-Verlag 2011
Dear Editor,
Here, we report a case of acquired severe aplastic anemia
(SAA) which occurred in a young man potentially
correlated to the administration of H1N1 influenza virus
vaccine. On 30 November 2009, a 25-year-old man
presented to ER with fever, headache, sore throat and
diffuse bruises. Laboratory tests revealed severe pancytopenia
(WBC 1.2?109/L, haemoglobin 11.2 g/dL and
platelets 3,000?109/L).
He was immediately referred to our institution. Liver and
renal functions were normal as well as coagulation
parameters. Medical history was completely negative with
the exception that he received vaccination for H1N1 virus
few days before, on 15 November 2009 (Focetria, lot
number # 090201). He was completely healthy before. The
only reason why his family doctor suggested this specific
vaccination was because he worked as a salesman,
travelling abroad frequently...
