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Niemann-Pick C1 (NPC1) is found in the membranes of tiny enzyme-filled compartments known as lysosomes that digest and recycle cellular components and are located within cells.
"Our study reveals NPC1 to be an Achilles' heel for Ebola virus infection," says co-study leader Kartik Chandran, an associate professor of microbiology and immunology at Albert Einstein College of Medicine of Yeshiva University, NY.
"Mice lacking both copies of the NPC1 gene, and therefore devoid of the NPC1 protein, were completely resistant to infection."
