tetano
Editor, Senior Moderator
ACG Case Rep J
. 2022 Mar 28;9(3):e00753.
doi: 10.14309/crj.0000000000000753. eCollection 2022 Mar.
Severe Cholestatic Hepatitis Secondary to SARS-CoV-2
Christopher R Lindholm[SUP] 1 [/SUP], Xiaofei Zhang[SUP] 2 [/SUP], Erin K Spengler[SUP] 1 [/SUP], Kimberly E Daniel[SUP] 1 [/SUP]
Affiliations
Abstract
Liver injury is a common manifestation of coronavirus disease 2019 (COVID-19), with most injuries manifesting as transient mild hepatocellular injury. Cholestatic injury occurs less commonly and is typically mild. Severe cholestatic injury is rare, with only 4 cases reported in the literature. We present a 70-year-old woman with no known liver disease who presented with severe COVID-19 and developed severe cholestatic hepatitis. A liver biopsy was performed demonstrating bile duct injury, uncommonly reported in patients with COVID-19. This complication needs greater awareness because it has been known to cause progressive liver disease requiring transplantation.
. 2022 Mar 28;9(3):e00753.
doi: 10.14309/crj.0000000000000753. eCollection 2022 Mar.
Severe Cholestatic Hepatitis Secondary to SARS-CoV-2
Christopher R Lindholm[SUP] 1 [/SUP], Xiaofei Zhang[SUP] 2 [/SUP], Erin K Spengler[SUP] 1 [/SUP], Kimberly E Daniel[SUP] 1 [/SUP]
Affiliations
- PMID: 35359752
- PMCID: PMC8963841
- DOI: 10.14309/crj.0000000000000753
Abstract
Liver injury is a common manifestation of coronavirus disease 2019 (COVID-19), with most injuries manifesting as transient mild hepatocellular injury. Cholestatic injury occurs less commonly and is typically mild. Severe cholestatic injury is rare, with only 4 cases reported in the literature. We present a 70-year-old woman with no known liver disease who presented with severe COVID-19 and developed severe cholestatic hepatitis. A liver biopsy was performed demonstrating bile duct injury, uncommonly reported in patients with COVID-19. This complication needs greater awareness because it has been known to cause progressive liver disease requiring transplantation.