tetano
Editor, Senior Moderator
Pak J Pharm Sci. 2015 May;28(3 Suppl):1109-14.
[h=1]Abnormal expressions of inflammatory-related mediators and inhibition of fat metabolism in mice infected with influenza a virus.[/h] Yao M[SUP]1[/SUP], Wang L[SUP]2[/SUP], Yao D[SUP]3[/SUP], Yao D[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The pathophysiological role of influenza infection is poorly understood. In this study, one non-neurovirulent virus (IAV/Aichi/2/68/H3N2) strain was used to infect intra-nasally mice at different age to investigate the mechanism of cerebral edema formation and lower activities of mitochondria enzymes after influenza A virus (IAV) infection. Mice suffered 46.4% mortality in newborn compared with 96.0% in weanling, 100% in adult on day 7, respectively. IAV-RNA was easily detected in the brain of newborn mice. Significant production of endothelin-1 and inducible nitric oxide syntheses were increased on the 3rd and 5th day after IAV infection, associated with increasing blood-brain barrier permeability, brain edema formation and the higher mortality of animals. Production of tumor necrosis factor-α was related to inhibition of mitochondrial enzyme activities, suggesting that over expression of inflammatory cytokines and lower enzyme activities in mitochondria after IAV infection.
PMID: 26051732 [PubMed - in process]
[h=1]Abnormal expressions of inflammatory-related mediators and inhibition of fat metabolism in mice infected with influenza a virus.[/h] Yao M[SUP]1[/SUP], Wang L[SUP]2[/SUP], Yao D[SUP]3[/SUP], Yao D[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The pathophysiological role of influenza infection is poorly understood. In this study, one non-neurovirulent virus (IAV/Aichi/2/68/H3N2) strain was used to infect intra-nasally mice at different age to investigate the mechanism of cerebral edema formation and lower activities of mitochondria enzymes after influenza A virus (IAV) infection. Mice suffered 46.4% mortality in newborn compared with 96.0% in weanling, 100% in adult on day 7, respectively. IAV-RNA was easily detected in the brain of newborn mice. Significant production of endothelin-1 and inducible nitric oxide syntheses were increased on the 3rd and 5th day after IAV infection, associated with increasing blood-brain barrier permeability, brain edema formation and the higher mortality of animals. Production of tumor necrosis factor-α was related to inhibition of mitochondrial enzyme activities, suggesting that over expression of inflammatory cytokines and lower enzyme activities in mitochondria after IAV infection.
PMID: 26051732 [PubMed - in process]