sharon sanders
Editor-in-Chief & President
[h=1]Expanded Spectrum of Congenital Ocular Findings in Microcephaly with Presumed Zika Infection[/h] Homero Augusto de Miranda II, MD
, Marcelo Cavalcante Costa, MD
, Maria Auxiliadora Monteiro Fraz?o, MD
, Nat?lia Sim?o, MD
, Sandra Franchischini, MD
, Darius M. Moshfeghi, MD
Manuscript no. 2016-209.
DOI: http://dx.doi.org/10.1016/j.ophtha.2016.05.001
[h=2]
Article Info[/h]
[h=3]snip[/h]
[h=3]Results[/h] Three male infants were born with microcephaly to mothers who had a viral syndrome during the first trimester of gestation in an area that subsequently has demonstrated epidemic Zika infection, a flavivirus related to Dengue. Ocular examination was performed. All 6 eyes demonstrated a pigmentary maculopathy ranging from mild to pronounced. In 4 eyes, well-delineated macular chorioretinal atrophy with a hyperpigmented ring developed. Three eyes demonstrated vascular tortuosity and 2 eyes demonstrated a pronounced early termination of the retinal vasculature on photographic evaluation. Two eyes demonstrated a washed out peripheral retina with a hypolucent spot. One eye had scattered subretinal hemorrhages external to the macula. Finally, 1 eye demonstrated peripheral pigmentary changes and clustered atrophic lesions resembling grouped congenital albinotic spots (polar bear tracks).
[h=3]Conclusions[/h] Zika virus has been linked to microcephaly in children of mothers with a viral syndrome during the first trimester of pregnancy. Ocular findings previously described a pigmentary retinopathy and atrophy that now can be expanded to include torpedo maculopathy, vascular changes, and hemorrhagic retinopathy. Ophthalmologic screening guidelines need to be defined to determine which children would benefit from newborn screening in affected regions.
http://www.aaojournal.org/article/S0161-6420(16)30277-9/abstract
hat tip Michael Coston and Crof for the link
, Marcelo Cavalcante Costa, MD
, Maria Auxiliadora Monteiro Fraz?o, MD
, Nat?lia Sim?o, MD
, Sandra Franchischini, MD
, Darius M. Moshfeghi, MD
Manuscript no. 2016-209.
DOI: http://dx.doi.org/10.1016/j.ophtha.2016.05.001
[h=2]
Article Info[/h] [h=3]snip[/h]
[h=3]Results[/h] Three male infants were born with microcephaly to mothers who had a viral syndrome during the first trimester of gestation in an area that subsequently has demonstrated epidemic Zika infection, a flavivirus related to Dengue. Ocular examination was performed. All 6 eyes demonstrated a pigmentary maculopathy ranging from mild to pronounced. In 4 eyes, well-delineated macular chorioretinal atrophy with a hyperpigmented ring developed. Three eyes demonstrated vascular tortuosity and 2 eyes demonstrated a pronounced early termination of the retinal vasculature on photographic evaluation. Two eyes demonstrated a washed out peripheral retina with a hypolucent spot. One eye had scattered subretinal hemorrhages external to the macula. Finally, 1 eye demonstrated peripheral pigmentary changes and clustered atrophic lesions resembling grouped congenital albinotic spots (polar bear tracks).
[h=3]Conclusions[/h] Zika virus has been linked to microcephaly in children of mothers with a viral syndrome during the first trimester of pregnancy. Ocular findings previously described a pigmentary retinopathy and atrophy that now can be expanded to include torpedo maculopathy, vascular changes, and hemorrhagic retinopathy. Ophthalmologic screening guidelines need to be defined to determine which children would benefit from newborn screening in affected regions.
http://www.aaojournal.org/article/S0161-6420(16)30277-9/abstract
hat tip Michael Coston and Crof for the link