tetano
Editor, Senior Moderator
AACE Clin Case Rep
. 2021 Dec 16.
doi: 10.1016/j.aace.2021.12.002. Online ahead of print.
Thyroiditis after Coronavirus Disease 2019 (COVID-19) mRNA Vaccine: A Case Series
Manthan Pandya[SUP] 1 [/SUP], Geethika Thota[SUP] 2 [/SUP], Xiangbing Wang[SUP] 1 [/SUP], Hongxiu Luo[SUP] 2 [/SUP]
Affiliations
Abstract
Background: While SARS-COV-2 virus infection was reported to cause subacute thyroiditis, the mRNA vaccine for SARS-COV-2 was suspected to induce thyroiditis with thyrotoxicosis.
Case report: We describe three patients without a history of thyroid disease who presented with symptomatic, biochemical, and radiological evidence of thyroiditis with thyrotoxicosis, 10-20 days after receiving either the Pfizer Bio-NTech or the Moderna COVID-19 mRNA vaccine. All presented with thyrotoxicosis, but with negative thyroid stimulating immunoglobulins for Graves' disease and no autonomous nodules. Two patients underwent thyroid uptake and scan which confirmed thyroiditis. One patient had significantly increased erythrocyte sedimentation rate (ESR) and Interleukin-6 (IL-6). All had improvement in symptoms with non-steroidal anti-inflammatory drugs (NSAIDs), with one patient eventually requiring steroids for symptom control.
Discussion: The mRNA vaccine for SARS-COV-2 was associated with thyroiditis and presented with thyrotoxicosis. Elevated proinflammatory markers and cytokines after vaccines may play a major role.
Conclusion: Our case series report highlights a possible relationship between the COVID-19 mRNA vaccine and thyroiditis with thyrotoxicosis, which previously not recognized by health providers.
Keywords: COVID-19; Subacute Thyroiditis; mRNA vaccine.
. 2021 Dec 16.
doi: 10.1016/j.aace.2021.12.002. Online ahead of print.
Thyroiditis after Coronavirus Disease 2019 (COVID-19) mRNA Vaccine: A Case Series
Manthan Pandya[SUP] 1 [/SUP], Geethika Thota[SUP] 2 [/SUP], Xiangbing Wang[SUP] 1 [/SUP], Hongxiu Luo[SUP] 2 [/SUP]
Affiliations
- PMID: 34934810
- PMCID: PMC8675183
- DOI: 10.1016/j.aace.2021.12.002
Abstract
Background: While SARS-COV-2 virus infection was reported to cause subacute thyroiditis, the mRNA vaccine for SARS-COV-2 was suspected to induce thyroiditis with thyrotoxicosis.
Case report: We describe three patients without a history of thyroid disease who presented with symptomatic, biochemical, and radiological evidence of thyroiditis with thyrotoxicosis, 10-20 days after receiving either the Pfizer Bio-NTech or the Moderna COVID-19 mRNA vaccine. All presented with thyrotoxicosis, but with negative thyroid stimulating immunoglobulins for Graves' disease and no autonomous nodules. Two patients underwent thyroid uptake and scan which confirmed thyroiditis. One patient had significantly increased erythrocyte sedimentation rate (ESR) and Interleukin-6 (IL-6). All had improvement in symptoms with non-steroidal anti-inflammatory drugs (NSAIDs), with one patient eventually requiring steroids for symptom control.
Discussion: The mRNA vaccine for SARS-COV-2 was associated with thyroiditis and presented with thyrotoxicosis. Elevated proinflammatory markers and cytokines after vaccines may play a major role.
Conclusion: Our case series report highlights a possible relationship between the COVID-19 mRNA vaccine and thyroiditis with thyrotoxicosis, which previously not recognized by health providers.
Keywords: COVID-19; Subacute Thyroiditis; mRNA vaccine.