tetano
Editor, Senior Moderator
Infect Control Hosp Epidemiol 2010;31:382?387
? 2010 by The Society for Healthcare Epidemiology of America. All rights reserved.
0899-823X/2010/3104-0010$15.00
DOI: 10.1086/651095
Original Article
A Time‐Series Analysis of Clostridium difficile and Its Seasonal Association with Influenza
Philip M. Polgreen, MD, MPH;
Ming Yang, MS;
Lucas C. Bohnett, MS;
Joseph E. Cavanaugh, PhD
From the Department of Internal Medicine, University of Iowa Carver College of Medicine (P.M.P.), and the Departments of Epidemiology (P.M.P.) and Biostatistics (M.Y., L.C.B., J.E.C.), University of Iowa College of Public Health, Iowa City, Iowa.
Objective.To characterize the temporal progression of the monthly incidence of Clostridium difficile infections (CDIs) and to determine whether the incidence of CDI is related to the incidence of seasonal influenza.
Design.A retrospective study of patients in the Nationwide Inpatient Sample during the period from 1998 through 2005.
Methods.We identified all hospitalizations with a primary or secondary diagnosis of CDI with use of International Classification of Diseases, 9th Revision, Clinical Modification codes, and we did the same for influenza. The incidence of CDI was modeled as an autoregression about a linear trend. To investigate the association of CDI with influenza, we compared national and regional CDI and influenza series data and calculated cross‐correlation functions with data that had been prewhitened (filtered to remove temporal patterns common to both series). To estimate the burden of seasonal CDI, we developed a proportional measure of seasonal CDI.
Results.Time‐series analysis of the monthly number of CDI cases reveals a distinct positive linear trend and a clear pattern of seasonal variation ( ). The cross‐correlation functions indicate that influenza activity precedes CDI activity on both a national and regional basis. The average burden of seasonal (ie, winter) CDI is 23%.
Conclusions.The epidemiologic characteristics of CDI follow a pattern that is seasonal and associated with influenza, which is likely due to antimicrobial use during influenza seasons. Approximately 23% of average monthly CDI during the peak 3 winter months could be eliminated if CDI remained at summer levels.
http://www.journals.uchicago.edu/do...%7Cany%3A+influenza+h1n1%5D&searchHistoryKey=
? 2010 by The Society for Healthcare Epidemiology of America. All rights reserved.
0899-823X/2010/3104-0010$15.00
DOI: 10.1086/651095
Original Article
A Time‐Series Analysis of Clostridium difficile and Its Seasonal Association with Influenza
Philip M. Polgreen, MD, MPH;
Ming Yang, MS;
Lucas C. Bohnett, MS;
Joseph E. Cavanaugh, PhD
From the Department of Internal Medicine, University of Iowa Carver College of Medicine (P.M.P.), and the Departments of Epidemiology (P.M.P.) and Biostatistics (M.Y., L.C.B., J.E.C.), University of Iowa College of Public Health, Iowa City, Iowa.
Objective.To characterize the temporal progression of the monthly incidence of Clostridium difficile infections (CDIs) and to determine whether the incidence of CDI is related to the incidence of seasonal influenza.
Design.A retrospective study of patients in the Nationwide Inpatient Sample during the period from 1998 through 2005.
Methods.We identified all hospitalizations with a primary or secondary diagnosis of CDI with use of International Classification of Diseases, 9th Revision, Clinical Modification codes, and we did the same for influenza. The incidence of CDI was modeled as an autoregression about a linear trend. To investigate the association of CDI with influenza, we compared national and regional CDI and influenza series data and calculated cross‐correlation functions with data that had been prewhitened (filtered to remove temporal patterns common to both series). To estimate the burden of seasonal CDI, we developed a proportional measure of seasonal CDI.
Results.Time‐series analysis of the monthly number of CDI cases reveals a distinct positive linear trend and a clear pattern of seasonal variation ( ). The cross‐correlation functions indicate that influenza activity precedes CDI activity on both a national and regional basis. The average burden of seasonal (ie, winter) CDI is 23%.
Conclusions.The epidemiologic characteristics of CDI follow a pattern that is seasonal and associated with influenza, which is likely due to antimicrobial use during influenza seasons. Approximately 23% of average monthly CDI during the peak 3 winter months could be eliminated if CDI remained at summer levels.
http://www.journals.uchicago.edu/do...%7Cany%3A+influenza+h1n1%5D&searchHistoryKey=