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A Tale of Two Mutations: Beginning to Understand the Problems with Egg-Based Influenza Vaccines?

tetano

Editor, Senior Moderator
Cell Host Microbe. 2019 Jun 12;25(6):773-775. doi: 10.1016/j.chom.2019.05.012.
[h=1]A Tale of Two Mutations: Beginning to Understand the Problems with Egg-Based Influenza Vaccines?[/h] Subbarao K[SUP]1[/SUP], Barr I[SUP]2[/SUP].
[h=3]Author information[/h]

[h=3]Abstract[/h] The majority of influenza vaccines are produced in embryonated eggs, but mutations occur as human influenza A(H3N2) viruses adapt to grow in eggs. This can alter virus antigenicity. Wu et al. (2019) reveal that there are two mutually exclusive pathways for egg adaptation, which has potential implications for future egg-based influenza vaccines.
Copyright ? 2019. Published by Elsevier Inc.


PMID: 31194938 DOI: 10.1016/j.chom.2019.05.012
 
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