tetano
Editor, Senior Moderator
Virology. 2015 Oct 1;486:146-157. doi: 10.1016/j.virol.2015.08.014. [Epub ahead of print]
[h=1]A systems approach to understanding human rhinovirus and influenza virus infection.[/h] Kim TK[SUP]1[/SUP], Bheda-Malge A[SUP]2[/SUP], Lin Y[SUP]3[/SUP], Sreekrishna K[SUP]4[/SUP], Adams R[SUP]5[/SUP], Robinson MK[SUP]6[/SUP], Bascom CC[SUP]7[/SUP], Tiesman JP[SUP]8[/SUP], Isfort RJ[SUP]9[/SUP], Gelinas R[SUP]10[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Human rhinovirus and influenza virus infections of the upper airway lead to colds and the flu and can trigger exacerbations of lower airway diseases including asthma and chronic obstructive pulmonary disease. Novel diagnostic and therapeutic targets are still needed to differentiate between the cold and the flu, since the clinical course of influenza can be severe while that of rhinovirus is usually more mild. In our investigation of influenza and rhinovirus infection of human respiratory epithelial cells, we used a systems approach to identify the temporally changing patterns of host gene expression from these viruses. After infection of human bronchial epithelial cells (BEAS-2B) with rhinovirus, influenza virus or co-infection with both viruses, we studied the time-course of host gene expression changes over three days. We modeled host responses to these viral infections with time and documented the qualitative and quantitative differences in innate immune activation and regulation.
Copyright ? 2015 The Authors. Published by Elsevier Inc. All rights reserved.
[h=4]KEYWORDS:[/h] Co-infection; Epithelial cell; Gene expression time-course; Influenza virus; Rhinovirus
PMID: 26437235 [PubMed - as supplied by publisher]
[h=1]A systems approach to understanding human rhinovirus and influenza virus infection.[/h] Kim TK[SUP]1[/SUP], Bheda-Malge A[SUP]2[/SUP], Lin Y[SUP]3[/SUP], Sreekrishna K[SUP]4[/SUP], Adams R[SUP]5[/SUP], Robinson MK[SUP]6[/SUP], Bascom CC[SUP]7[/SUP], Tiesman JP[SUP]8[/SUP], Isfort RJ[SUP]9[/SUP], Gelinas R[SUP]10[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Human rhinovirus and influenza virus infections of the upper airway lead to colds and the flu and can trigger exacerbations of lower airway diseases including asthma and chronic obstructive pulmonary disease. Novel diagnostic and therapeutic targets are still needed to differentiate between the cold and the flu, since the clinical course of influenza can be severe while that of rhinovirus is usually more mild. In our investigation of influenza and rhinovirus infection of human respiratory epithelial cells, we used a systems approach to identify the temporally changing patterns of host gene expression from these viruses. After infection of human bronchial epithelial cells (BEAS-2B) with rhinovirus, influenza virus or co-infection with both viruses, we studied the time-course of host gene expression changes over three days. We modeled host responses to these viral infections with time and documented the qualitative and quantitative differences in innate immune activation and regulation.
Copyright ? 2015 The Authors. Published by Elsevier Inc. All rights reserved.
[h=4]KEYWORDS:[/h] Co-infection; Epithelial cell; Gene expression time-course; Influenza virus; Rhinovirus
PMID: 26437235 [PubMed - as supplied by publisher]