tetano
Editor, Senior Moderator
BMC Infect Dis. 2016 Jan 5;16(1):3. doi: 10.1186/s12879-015-1298-9.
[h=1]A systematic review of reported reassortant viral lineages of influenza A.[/h] Pinsent A[SUP]1[/SUP], Fraser C[SUP]2[/SUP], Ferguson NM[SUP]3[/SUP], Riley S[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Most previous evolutionary studies of influenza A have focussed on genetic drift, or reassortment of specific gene segments, hosts or subtypes. We conducted a systematic literature review to identify reported claimed reassortant influenza A lineages with genomic data available in GenBank, to obtain 646 unique first-report isolates out of a possible 20,781 open-access genomes.
[h=4]RESULTS:[/h] After adjusting for correlations, only: swine as host, China, Europe, Japan and years between 1997 and 2002; remained as significant risk factors for the reporting of reassortant viral lineages. For swine H1, more reassortants were observed in the North American H1 clade compared with the Eurasian avian-like H1N1 clade. Conversely, for avian H5 isolates, a higher number of reported reassortants were observed in the European H5N2/H3N2 clade compared with the H5N2 North American clade.
[h=4]CONCLUSIONS:[/h] Despite unavoidable biases (publication, database choice and upload propensity) these results synthesize a large majority of the current literature on novel reported influenza A reassortants and are a potentially useful prerequisite to inform further algorithmic studies.
PMID: 26732146 [PubMed - in process] PMCID: PMC4702296 Free PMC Article
[h=1]A systematic review of reported reassortant viral lineages of influenza A.[/h] Pinsent A[SUP]1[/SUP], Fraser C[SUP]2[/SUP], Ferguson NM[SUP]3[/SUP], Riley S[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Most previous evolutionary studies of influenza A have focussed on genetic drift, or reassortment of specific gene segments, hosts or subtypes. We conducted a systematic literature review to identify reported claimed reassortant influenza A lineages with genomic data available in GenBank, to obtain 646 unique first-report isolates out of a possible 20,781 open-access genomes.
[h=4]RESULTS:[/h] After adjusting for correlations, only: swine as host, China, Europe, Japan and years between 1997 and 2002; remained as significant risk factors for the reporting of reassortant viral lineages. For swine H1, more reassortants were observed in the North American H1 clade compared with the Eurasian avian-like H1N1 clade. Conversely, for avian H5 isolates, a higher number of reported reassortants were observed in the European H5N2/H3N2 clade compared with the H5N2 North American clade.
[h=4]CONCLUSIONS:[/h] Despite unavoidable biases (publication, database choice and upload propensity) these results synthesize a large majority of the current literature on novel reported influenza A reassortants and are a potentially useful prerequisite to inform further algorithmic studies.
PMID: 26732146 [PubMed - in process] PMCID: PMC4702296 Free PMC Article