tetano
Editor, Senior Moderator
J Infect Dis. 2015 Feb 23. pii: jiv109. [Epub ahead of print]
[h=1]A Systematic Review and Meta-Analysis of the Seroprevalence of Influenza A (H9N2) Virus Infection Among Humans.[/h] Khan SU[SUP]1[/SUP], Anderson BD[SUP]2[/SUP], Heil GL[SUP]3[/SUP], Liang S[SUP]3[/SUP], Gray GC[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]INTRODUCTION:[/h] Given that Influenza A (H9N2) subtype viruses are recognized as a pandemic threat, we evaluated the overall burden of H9N2 infections among avian-exposed human populations.
[h=4]METHODS:[/h] We performed a systematic literature search in PubMed, AGRICOLA, and Cab Abstracts databases from 1997 to 2013. Studies reporting serological evidence of human Influenza A(H9N2) infection among avian-exposed populations were included. We used a WHO-recommended case definition for serological evidence of infection through hemagglutination inhibition (HI) and microneutralization (MN) assays. We calculated overall seroprevalance through a random effects meta-analysis model.
[h=4]RESULTS:[/h] Seroprevalence figures reported by the studies ranged from 1% to 43% (median: 9%) by HI, which was not significantly different from the seroprevalence estimated through the WHO-recommended case definition (median: 1.3%, range:0.5%-42.6%). Reported seroprevalence by MN ranged from 0.6% to 9% (median: 2.7%), which was greater than the seroprevalence estimated through the WHO-recommended case definition (median: 0.3%, range: 0.1%-1.4%).
[h=4]CONCLUSION:[/h] A small proportion of avian-exposed humans had evidence of H9N2 infection. As the virus has a near global distribution in poultry, it seems likely that present surveillance efforts are missing mild or asymptomatic infections among avian-exposed persons. It seems prudent to closely monitor avian-exposed populations for H9N2 infection to provide pre-pandemic warnings.
? The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
PMID: 25712969 [PubMed - as supplied by publisher]
[h=1]A Systematic Review and Meta-Analysis of the Seroprevalence of Influenza A (H9N2) Virus Infection Among Humans.[/h] Khan SU[SUP]1[/SUP], Anderson BD[SUP]2[/SUP], Heil GL[SUP]3[/SUP], Liang S[SUP]3[/SUP], Gray GC[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]INTRODUCTION:[/h] Given that Influenza A (H9N2) subtype viruses are recognized as a pandemic threat, we evaluated the overall burden of H9N2 infections among avian-exposed human populations.
[h=4]METHODS:[/h] We performed a systematic literature search in PubMed, AGRICOLA, and Cab Abstracts databases from 1997 to 2013. Studies reporting serological evidence of human Influenza A(H9N2) infection among avian-exposed populations were included. We used a WHO-recommended case definition for serological evidence of infection through hemagglutination inhibition (HI) and microneutralization (MN) assays. We calculated overall seroprevalance through a random effects meta-analysis model.
[h=4]RESULTS:[/h] Seroprevalence figures reported by the studies ranged from 1% to 43% (median: 9%) by HI, which was not significantly different from the seroprevalence estimated through the WHO-recommended case definition (median: 1.3%, range:0.5%-42.6%). Reported seroprevalence by MN ranged from 0.6% to 9% (median: 2.7%), which was greater than the seroprevalence estimated through the WHO-recommended case definition (median: 0.3%, range: 0.1%-1.4%).
[h=4]CONCLUSION:[/h] A small proportion of avian-exposed humans had evidence of H9N2 infection. As the virus has a near global distribution in poultry, it seems likely that present surveillance efforts are missing mild or asymptomatic infections among avian-exposed persons. It seems prudent to closely monitor avian-exposed populations for H9N2 infection to provide pre-pandemic warnings.
? The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
PMID: 25712969 [PubMed - as supplied by publisher]