Ganseerpel
Advisory Board, Senior Moderator
Published online before print March 7, 2007
Proc. Natl. Acad. Sci. USA, 10.1073/pnas.0700435104
Evolution
A statistical phylogeography of influenza A H5N1
( phylogeny | geography | epidemiology | parallelism | diffusion )
Robert G. Wallace , HoangMinh HoDac , Richard H. Lathrop , and Walter M. Fitch
Department of Ecology and Evolutionary Biology, University of California, 321 Steinhaus Hall, Irvine, CA 92697; and Donald Bren School of Information and Computer Sciences, University of California, 444 Computer Science Building, Irvine, CA 92697
Contributed by Walter M. Fitch, January 17, 2007 (sent for review November 10, 2006)
The geographic diffusion of highly pathogenic influenza A H5N1 has largely been traced from the perspective of the virus's victims. Birds of a variety of avian orders have been sampled across localities, and their infection has been identified by a general genetic test. Another approach tracks the migration from the perspective of the virus alone, by way of a phylogeography of H5N1 genetic sequences. Although several phylogenies in the literature have labeled H5N1 clades by geographic region, none has analytically inferred the history of the virus's migration. With a statistical phylogeography of 192 hemagglutinin and neuraminidase isolates, we show that the Chinese province of Guangdong is the source of multiple H5N1 strains spreading at both regional and international scales. In contrast, Indochina appears to be a regional sink, at the same time demonstrating bidirectional dispersal among localities within the region. An evolutionary trace of HA1 across the phylogeography suggests a mechanism by which H5N1 is able to infect repeated cycles of host species across localities, regardless of the host species first infected in each locale. The trace also hypothesizes amino acid replacements that preceded the first recorded outbreak of pathogenic H5N1 in Hong Kong, 1997.
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Proc. Natl. Acad. Sci. USA, 10.1073/pnas.0700435104
Evolution
A statistical phylogeography of influenza A H5N1
( phylogeny | geography | epidemiology | parallelism | diffusion )
Robert G. Wallace , HoangMinh HoDac , Richard H. Lathrop , and Walter M. Fitch
Department of Ecology and Evolutionary Biology, University of California, 321 Steinhaus Hall, Irvine, CA 92697; and Donald Bren School of Information and Computer Sciences, University of California, 444 Computer Science Building, Irvine, CA 92697
Contributed by Walter M. Fitch, January 17, 2007 (sent for review November 10, 2006)
The geographic diffusion of highly pathogenic influenza A H5N1 has largely been traced from the perspective of the virus's victims. Birds of a variety of avian orders have been sampled across localities, and their infection has been identified by a general genetic test. Another approach tracks the migration from the perspective of the virus alone, by way of a phylogeography of H5N1 genetic sequences. Although several phylogenies in the literature have labeled H5N1 clades by geographic region, none has analytically inferred the history of the virus's migration. With a statistical phylogeography of 192 hemagglutinin and neuraminidase isolates, we show that the Chinese province of Guangdong is the source of multiple H5N1 strains spreading at both regional and international scales. In contrast, Indochina appears to be a regional sink, at the same time demonstrating bidirectional dispersal among localities within the region. An evolutionary trace of HA1 across the phylogeography suggests a mechanism by which H5N1 is able to infect repeated cycles of host species across localities, regardless of the host species first infected in each locale. The trace also hypothesizes amino acid replacements that preceded the first recorded outbreak of pathogenic H5N1 in Hong Kong, 1997.
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