tetano
Editor, Senior Moderator
Angew Chem Int Ed Engl. 2012 Jan 26. doi: 10.1002/anie.201108245. [Epub ahead of print]
A Secondary Sialic Acid Binding Site on Influenza Virus Neuraminidase: Fact or Fiction?
Lai JC, Garcia JM, Dyason JC, B?hm R, Madge PD, Rose FJ, Nicholls JM, Peiris JS, Haselhorst T, von Itzstein M.
Source
Hong Kong University-Pasteur Research Centre, SAR (China).
Abstract
One flu over the cuckoo's nest: The biological significance of a secondary sialic acid binding site on influenza virus neuraminidase remains elusive. On blocking the active site influenza-virus-containing virus-like particles with oseltamivir carboxylate, binding to α(2,3)-sialyllactose is still detected. Thus the sialyllactose must bind at a secondary sialic acid binding site (see structures: docking study of α(2,3)-sialyllactose in the secondary binding site of avian flu neuraminidase).
Copyright ? 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
PMID:
22281708
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22281708
A Secondary Sialic Acid Binding Site on Influenza Virus Neuraminidase: Fact or Fiction?
Lai JC, Garcia JM, Dyason JC, B?hm R, Madge PD, Rose FJ, Nicholls JM, Peiris JS, Haselhorst T, von Itzstein M.
Source
Hong Kong University-Pasteur Research Centre, SAR (China).
Abstract
One flu over the cuckoo's nest: The biological significance of a secondary sialic acid binding site on influenza virus neuraminidase remains elusive. On blocking the active site influenza-virus-containing virus-like particles with oseltamivir carboxylate, binding to α(2,3)-sialyllactose is still detected. Thus the sialyllactose must bind at a secondary sialic acid binding site (see structures: docking study of α(2,3)-sialyllactose in the secondary binding site of avian flu neuraminidase).
Copyright ? 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
PMID:
22281708
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22281708