tetano
Editor, Senior Moderator
Chem Commun (Camb). 2013 Nov 18. [Epub ahead of print]
A novel small-molecule binds to the influenza A virus RNA promoter and inhibits viral replication.
Lee MK, Bottini A, Kim M, Bardaro MF, Zhang Z, Pellecchia M, Choi BS, Varani G.
Source
Department of Chemistry, University of Washington, Box 351700, Seattle, WA 98195, USA. varani@chem.washington.edu.
Abstract
Through screening by NMR spectroscopy, we discovered a novel scaffold (DPQ: 6,7-dimethoxy-2-(1-piperazinyl)-4-quinazolinamine) that binds specifically to the influenza A virus RNA promoter. The solution structure of the RNA-DPQ complex reported here demonstrates that the internal loop is the binding site of DPQ. The scaffold exhibits antiviral activity against influenza viruses.
PMID:
24247110
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24247110
A novel small-molecule binds to the influenza A virus RNA promoter and inhibits viral replication.
Lee MK, Bottini A, Kim M, Bardaro MF, Zhang Z, Pellecchia M, Choi BS, Varani G.
Source
Department of Chemistry, University of Washington, Box 351700, Seattle, WA 98195, USA. varani@chem.washington.edu.
Abstract
Through screening by NMR spectroscopy, we discovered a novel scaffold (DPQ: 6,7-dimethoxy-2-(1-piperazinyl)-4-quinazolinamine) that binds specifically to the influenza A virus RNA promoter. The solution structure of the RNA-DPQ complex reported here demonstrates that the internal loop is the binding site of DPQ. The scaffold exhibits antiviral activity against influenza viruses.
PMID:
24247110
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24247110