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A Nevada lab confirmed the first coronavirus reinfection in the U.S., a case that included severe symptoms.

Gert van der Hoek

In Memoriam - Editor, Senior Moderator
A public health laboratory in Nevada has reported the first confirmed coronavirus reinfection in the United States, and the first in the world known to have brought on severe symptoms.

The first three confirmed reinfections in the world were reported this week, one in Hong Kong and two in Europe, all mild.

Reinfection does not surprise researchers, given the millions of cases around the world, but it is not yet clear if such cases — particularly severe ones — are anomalies or will prove common.

The patient is a 25-year-old man in Reno who apparently experienced a second bout of infection just 48 days after his first, according to health officials in Nevada.

Experts have said that even low levels of antibodies and T cells in response to infection should last for a few months and provide some protection against the virus, which appears to have been borne out in the other confirmed reinfections.

The patient in Nevada had a sore throat, cough, nausea and diarrhea starting on March 25. He tested positive on April 18, recovered by April 27, and tested negative twice. He began to feel unwell again on May 28, and three days later sought help for a similar set of symptoms.

He was hospitalized on June 5 for shortness of breath and needed oxygen; an X-ray showed the “ground-glass opacities” typical of Covid-19.

Researchers genetically sequenced the viruses from each bout, and found they were too different to be accounted for by an extended first illness. The findings have been submitted for consideration to the Lancet Infectious Diseases journal.
 
Genomic Evidence for a Case of Reinfection with SARS-CoV-2


16 Pages Posted: 27 Aug 2020
RICHARD TILLETT


Nevada Institute for Personalized Medicine; Nevada Center for Bioinformatics
JOEL SEVINSKY


THEIAGEN CONSULTING
PAUL HARTLEY


University of Nevada, Reno
HEATHER KERWIN


WASHOE COUNTY HEALTH DISTRICT
NATALIE CRAWFORD


RENOWN HEALTH
ANDREW GORZALSKI


University of Nevada, Reno - NEVADA STATE PUBLIC HEALTH LABORATORY
CHRISTOPHER LAVERDURE


University of Nevada, Reno - NEVADA STATE PUBLIC HEALTH LABORATORY
SUBHASH VERMA


UNIVERSITY OF NEVADA RENO SCHOOL OF MEDICINE
CYPRIAN ROSSETTO


UNIVERSITY OF NEVADA RENO SCHOOL OF MEDICINE
MEGAN FARRELL


WASHOE COUNTY SHERIFF'S FORENSIC SCIENCE DIVISION
DAVID JACKSON


WASHOE COUNTY SHERIFF'S FORENSIC SCIENCE DIVISION
Mark Pandori


NEVADA STATE PUBLIC HEALTH LABORATORY, UNIVERSITY OF NEVADA, RENO SCHOOL OF MEDICINE
STEPHANIE VAN HOOSER


University of Nevada, Reno - NEVADA STATE PUBLIC HEALTH LABORATORY

More...
Abstract


The degree of protective immunity conferred by infection with SARS-CoV-2 is currently unknown. As such, the possibility of reinfection with this virus is not well understood. Herein, we describe the data from an investigation of two instances of SARS-CoV-2 infection in the same individual. Through nucleic acid sequence analysis, the viruses associated with each instance of infection were found to possess a degree of genetic discordance that cannot be explained reasonably through short-term in vivo evolution. We conclude that it is possible for humans to become infected multiple times by SARS-CoV-2, but the generalizability of this finding is not known.

Funding Statement: Nevada IDEA Network of Biomedical Research (INBRE) supported this work and the publication was made possible by grants from the National Institute of General Medical Sciences (GM103440 and GM104944) from the National Institutes of Health.

Declaration of Interests: Missing.

Ethics Approval Statement: Missing.



Keywords: SARS-COV-2, CORONAVIRUS, SEQUENCE, REINFECTION

Suggested Citation:

TILLETT, RICHARD and SEVINSKY, JOEL and HARTLEY, PAUL and KERWIN, HEATHER and CRAWFORD, NATALIE and GORZALSKI, ANDREW and LAVERDURE, CHRISTOPHER and VERMA, SUBHASH and ROSSETTO, CYPRIAN and FARRELL, MEGAN and JACKSON, DAVID and Pandori, Mark and VAN HOOSER, STEPHANIE, Genomic Evidence for a Case of Reinfection with SARS-CoV-2. THELANCETID-D-20-05376, Available at SSRN: https://ssrn.com/abstract=3681489
...
https://papers.ssrn.com/sol3/papers....act_id=3681489
 
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